EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Orthologs

Description

Ensembl ID: ENSPMAG00000005184 (Gene tree)
Gene ID: -
Gene Symbol: rnf113a
Alias: -
Full Name: ring finger protein 113A
Gene Type: protein_coding
Species: Petromyzon_marinus
Status: putative
Strand: Minus strand
Length: 7899 bases
Position: chrGL476331:784411-792309
Accession: ZDB-GENE-040825-1
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSPMAP00000005756	zf-CCCH	PF00642.24	3.2e-09	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSPMAT00000005781	-	882	-	ENSPMAP00000005756	294 (aa)	-	S4RKM3

Gene Model

Click here to download ENSPMAG00000005184's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSPMAG00000005184's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSPMAG00000005184	rnf113a	99	68.333	ENSG00000125352	RNF113A	87	69.024	Homo_sapiens
ENSPMAG00000005184	rnf113a	94	58.545	ENSG00000139797	RNF113B	84	58.545	Homo_sapiens
ENSPMAG00000005184	rnf113a	92	78.229	ENSAPOG00000017510	rnf113a	84	78.229	Acanthochromis_polyacanthus
ENSPMAG00000005184	rnf113a	97	67.797	ENSAMEG00000019845	-	85	68.456	Ailuropoda_melanoleuca
ENSPMAG00000005184	rnf113a	76	77.232	ENSACIG00000007458	rnf113a	78	73.577	Amphilophus_citrinellus
ENSPMAG00000005184	rnf113a	92	78.229	ENSAOCG00000003485	rnf113a	84	78.229	Amphiprion_ocellaris
ENSPMAG00000005184	rnf113a	92	78.229	ENSAPEG00000001084	rnf113a	84	78.229	Amphiprion_percula
ENSPMAG00000005184	rnf113a	92	77.778	ENSATEG00000022950	rnf113a	84	77.778	Anabas_testudineus
ENSPMAG00000005184	rnf113a	85	75.984	ENSAPLG00000012510	-	94	75.984	Anas_platyrhynchos
ENSPMAG00000005184	rnf113a	87	76.744	ENSACAG00000012485	-	85	76.316	Anolis_carolinensis
ENSPMAG00000005184	rnf113a	89	73.034	ENSANAG00000024332	-	83	72.563	Aotus_nancymaae
ENSPMAG00000005184	rnf113a	93	60.440	ENSANAG00000020431	RNF113B	83	60.440	Aotus_nancymaae
ENSPMAG00000005184	rnf113a	98	69.463	ENSANAG00000013925	-	87	70.134	Aotus_nancymaae
ENSPMAG00000005184	rnf113a	92	76.838	ENSACLG00000025256	rnf113a	81	81.818	Astatotilapia_calliptera
ENSPMAG00000005184	rnf113a	91	77.985	ENSAMXG00000011273	rnf113a	84	79.487	Astyanax_mexicanus
ENSPMAG00000005184	rnf113a	95	68.621	ENSBTAG00000006034	RNF113A	87	69.360	Bos_taurus
ENSPMAG00000005184	rnf113a	97	65.292	ENSBTAG00000008684	-	84	65.306	Bos_taurus
ENSPMAG00000005184	rnf113a	94	49.301	WBGene00010476	rnf-113	78	49.669	Caenorhabditis_elegans
ENSPMAG00000005184	rnf113a	80	68.376	ENSCJAG00000004501	RNF113B	83	62.132	Callithrix_jacchus
ENSPMAG00000005184	rnf113a	97	69.048	ENSCJAG00000022327	RNF113A	87	69.333	Callithrix_jacchus
ENSPMAG00000005184	rnf113a	95	68.027	ENSCAFG00000018430	-	86	68.439	Canis_familiaris
ENSPMAG00000005184	rnf113a	98	58.804	ENSCAFG00000018373	-	86	60.465	Canis_familiaris
ENSPMAG00000005184	rnf113a	95	59.864	ENSCAFG00020020280	-	86	60.797	Canis_lupus_dingo
ENSPMAG00000005184	rnf113a	95	68.027	ENSCAFG00020004044	-	86	68.439	Canis_lupus_dingo
ENSPMAG00000005184	rnf113a	95	68.276	ENSCHIG00000018820	-	87	69.024	Capra_hircus
ENSPMAG00000005184	rnf113a	98	64.966	ENSCHIG00000015616	-	86	64.966	Capra_hircus
ENSPMAG00000005184	rnf113a	95	68.966	ENSTSYG00000001308	RNF113A	86	69.799	Carlito_syrichta
ENSPMAG00000005184	rnf113a	99	69.048	ENSCPOG00000038517	-	86	69.388	Cavia_porcellus
ENSPMAG00000005184	rnf113a	77	70.667	ENSCCAG00000021327	RNF113B	83	62.362	Cebus_capucinus
ENSPMAG00000005184	rnf113a	97	69.048	ENSCCAG00000013617	RNF113A	87	69.333	Cebus_capucinus
ENSPMAG00000005184	rnf113a	98	69.178	ENSCATG00000002702	RNF113A	85	69.521	Cercocebus_atys
ENSPMAG00000005184	rnf113a	99	67.333	ENSCLAG00000017479	-	86	68.687	Chinchilla_lanigera
ENSPMAG00000005184	rnf113a	82	68.880	ENSCSAG00000019472	-	85	61.034	Chlorocebus_sabaeus
ENSPMAG00000005184	rnf113a	79	66.953	ENSCSAG00000000222	RNF113B	82	59.220	Chlorocebus_sabaeus
ENSPMAG00000005184	rnf113a	72	73.023	ENSCHOG00000008711	-	85	72.000	Choloepus_hoffmanni
ENSPMAG00000005184	rnf113a	93	76.000	ENSCPBG00000026980	-	85	76.000	Chrysemys_picta_bellii
ENSPMAG00000005184	rnf113a	89	71.053	ENSCING00000009197	-	84	70.803	Ciona_intestinalis
ENSPMAG00000005184	rnf113a	76	78.571	ENSCSAVG00000006210	-	84	71.691	Ciona_savignyi
ENSPMAG00000005184	rnf113a	77	67.699	ENSCANG00000041552	RNF113B	85	60.000	Colobus_angolensis_palliatus
ENSPMAG00000005184	rnf113a	98	68.687	ENSCANG00000037715	RNF113A	87	69.024	Colobus_angolensis_palliatus
ENSPMAG00000005184	rnf113a	93	71.480	ENSCGRG00001002251	Rnf113a1	83	70.775	Cricetulus_griseus_chok1gshd
ENSPMAG00000005184	rnf113a	93	71.119	ENSCGRG00000019441	Rnf113a1	83	70.423	Cricetulus_griseus_crigri
ENSPMAG00000005184	rnf113a	94	70.463	ENSCGRG00000016675	Rnf113a2	86	69.416	Cricetulus_griseus_crigri
ENSPMAG00000005184	rnf113a	92	76.384	ENSCSEG00000021570	rnf113a	73	76.384	Cynoglossus_semilaevis
ENSPMAG00000005184	rnf113a	92	78.519	ENSCVAG00000011305	rnf113a	84	78.519	Cyprinodon_variegatus
ENSPMAG00000005184	rnf113a	92	78.598	ENSDARG00000037930	rnf113a	84	79.336	Danio_rerio
ENSPMAG00000005184	rnf113a	89	73.783	ENSDORG00000027624	Rnf113a2	83	71.986	Dipodomys_ordii
ENSPMAG00000005184	rnf113a	92	58.451	FBgn0038772	mdlc	82	58.725	Drosophila_melanogaster
ENSPMAG00000005184	rnf113a	92	73.260	ENSETEG00000018346	-	83	72.085	Echinops_telfairi
ENSPMAG00000005184	rnf113a	93	79.487	ENSEBUG00000016079	rnf113a	84	79.487	Eptatretus_burgeri
ENSPMAG00000005184	rnf113a	97	66.327	ENSEASG00005010538	-	86	67.003	Equus_asinus_asinus
ENSPMAG00000005184	rnf113a	95	69.310	ENSECAG00000003934	-	86	69.697	Equus_caballus
ENSPMAG00000005184	rnf113a	89	70.522	ENSECAG00000004638	-	86	70.909	Equus_caballus
ENSPMAG00000005184	rnf113a	96	74.035	ENSELUG00000020657	rnf113a	89	74.035	Esox_lucius
ENSPMAG00000005184	rnf113a	95	68.056	ENSFCAG00000028962	-	86	67.458	Felis_catus
ENSPMAG00000005184	rnf113a	95	69.204	ENSFCAG00000024392	-	83	69.257	Felis_catus
ENSPMAG00000005184	rnf113a	95	69.550	ENSFCAG00000025700	-	86	69.595	Felis_catus
ENSPMAG00000005184	rnf113a	93	74.545	ENSFALG00000004633	-	90	74.545	Ficedula_albicollis
ENSPMAG00000005184	rnf113a	90	78.947	ENSFHEG00000023305	rnf113a	85	78.676	Fundulus_heteroclitus
ENSPMAG00000005184	rnf113a	92	74.733	ENSGMOG00000004541	rnf113a	85	74.733	Gadus_morhua
ENSPMAG00000005184	rnf113a	94	74.101	ENSGALG00000000538	RNF113A	88	72.852	Gallus_gallus
ENSPMAG00000005184	rnf113a	92	79.779	ENSGAFG00000011863	rnf113a	84	79.779	Gambusia_affinis
ENSPMAG00000005184	rnf113a	92	77.256	ENSGACG00000009738	rnf113a	84	77.256	Gasterosteus_aculeatus
ENSPMAG00000005184	rnf113a	93	76.364	ENSGAGG00000020490	-	85	76.364	Gopherus_agassizii
ENSPMAG00000005184	rnf113a	94	58.909	ENSGGOG00000023052	RNF113B	84	58.909	Gorilla_gorilla
ENSPMAG00000005184	rnf113a	99	68.333	ENSGGOG00000002324	RNF113A	87	69.024	Gorilla_gorilla
ENSPMAG00000005184	rnf113a	92	77.206	ENSHBUG00000008626	rnf113a	84	78.309	Haplochromis_burtoni
ENSPMAG00000005184	rnf113a	99	67.797	ENSHGLG00000019571	-	84	68.493	Heterocephalus_glaber_female
ENSPMAG00000005184	rnf113a	99	66.113	ENSHGLG00100019582	-	85	67.450	Heterocephalus_glaber_male
ENSPMAG00000005184	rnf113a	93	75.636	ENSHCOG00000003421	rnf113a	85	75.636	Hippocampus_comes
ENSPMAG00000005184	rnf113a	91	80.000	ENSIPUG00000013431	RNF113A	84	80.220	Ictalurus_punctatus
ENSPMAG00000005184	rnf113a	94	71.174	ENSSTOG00000019866	-	83	71.127	Ictidomys_tridecemlineatus
ENSPMAG00000005184	rnf113a	72	60.377	ENSJJAG00000019849	Rnf113a1	96	52.788	Jaculus_jaculus
ENSPMAG00000005184	rnf113a	92	78.598	ENSKMAG00000009830	rnf113a	84	79.853	Kryptolebias_marmoratus
ENSPMAG00000005184	rnf113a	90	79.623	ENSLBEG00000004627	rnf113a	84	80.292	Labrus_bergylta
ENSPMAG00000005184	rnf113a	96	76.140	ENSLACG00000013178	rnf113a	88	76.140	Latimeria_chalumnae
ENSPMAG00000005184	rnf113a	92	79.336	ENSLOCG00000011785	rnf113a	84	79.336	Lepisosteus_oculatus
ENSPMAG00000005184	rnf113a	93	70.758	ENSLAFG00000013906	-	83	70.775	Loxodonta_africana
ENSPMAG00000005184	rnf113a	98	69.178	ENSMFAG00000018472	RNF113A	85	69.521	Macaca_fascicularis
ENSPMAG00000005184	rnf113a	98	69.178	ENSMMUG00000020223	RNF113A	85	69.521	Macaca_mulatta
ENSPMAG00000005184	rnf113a	98	69.178	ENSMNEG00000019778	RNF113A	85	69.521	Macaca_nemestrina
ENSPMAG00000005184	rnf113a	82	63.934	ENSMLEG00000038757	RNF113B	78	65.665	Mandrillus_leucophaeus
ENSPMAG00000005184	rnf113a	98	69.178	ENSMLEG00000020750	RNF113A	85	69.521	Mandrillus_leucophaeus
ENSPMAG00000005184	rnf113a	92	76.753	ENSMAMG00000021895	rnf113a	84	78.022	Mastacembelus_armatus
ENSPMAG00000005184	rnf113a	92	76.838	ENSMZEG00005023086	rnf113a	84	77.941	Maylandia_zebra
ENSPMAG00000005184	rnf113a	93	75.636	ENSMGAG00000001753	-	97	73.611	Meleagris_gallopavo
ENSPMAG00000005184	rnf113a	93	69.203	ENSMICG00000038084	-	83	69.014	Microcebus_murinus
ENSPMAG00000005184	rnf113a	97	67.568	ENSMICG00000001750	-	88	67.550	Microcebus_murinus
ENSPMAG00000005184	rnf113a	94	70.609	ENSMOCG00000005370	-	82	69.686	Microtus_ochrogaster
ENSPMAG00000005184	rnf113a	92	79.487	ENSMMOG00000016954	rnf113a	84	79.487	Mola_mola
ENSPMAG00000005184	rnf113a	92	70.696	ENSMALG00000007938	rnf113a	83	70.696	Monopterus_albus
ENSPMAG00000005184	rnf113a	94	72.598	MGP_CAROLIEiJ_G0017943	Rnf113a2	86	71.478	Mus_caroli
ENSPMAG00000005184	rnf113a	94	72.598	ENSMUSG00000098134	Rnf113a2	86	71.478	Mus_musculus
ENSPMAG00000005184	rnf113a	95	70.526	ENSMUSG00000036537	Rnf113a1	86	69.625	Mus_musculus
ENSPMAG00000005184	rnf113a	94	70.714	MGP_PahariEiJ_G0031547	Rnf113a1	83	70.423	Mus_pahari
ENSPMAG00000005184	rnf113a	94	72.598	MGP_PahariEiJ_G0029702	Rnf113a2	86	71.478	Mus_pahari
ENSPMAG00000005184	rnf113a	91	72.426	MGP_SPRETEiJ_G0034156	Rnf113a1	82	71.429	Mus_spretus
ENSPMAG00000005184	rnf113a	94	72.598	MGP_SPRETEiJ_G0018788	Rnf113a2	86	71.478	Mus_spretus
ENSPMAG00000005184	rnf113a	95	68.493	ENSMPUG00000019358	-	86	68.227	Mustela_putorius_furo
ENSPMAG00000005184	rnf113a	89	71.691	ENSMLUG00000016812	-	80	70.968	Myotis_lucifugus
ENSPMAG00000005184	rnf113a	89	70.849	ENSMLUG00000010856	-	81	70.504	Myotis_lucifugus
ENSPMAG00000005184	rnf113a	92	76.838	ENSNBRG00000004314	rnf113a	84	77.941	Neolamprologus_brichardi
ENSPMAG00000005184	rnf113a	77	67.841	ENSNLEG00000007844	RNF113B	84	60.364	Nomascus_leucogenys
ENSPMAG00000005184	rnf113a	99	68.333	ENSNLEG00000018333	RNF113A	87	69.024	Nomascus_leucogenys
ENSPMAG00000005184	rnf113a	91	71.273	ENSMEUG00000001855	-	84	71.277	Notamacropus_eugenii
ENSPMAG00000005184	rnf113a	92	77.574	ENSONIG00000000741	rnf113a	84	78.676	Oreochromis_niloticus
ENSPMAG00000005184	rnf113a	89	72.556	ENSOANG00000002592	-	81	71.795	Ornithorhynchus_anatinus
ENSPMAG00000005184	rnf113a	95	70.877	ENSOCUG00000016207	-	87	69.231	Oryctolagus_cuniculus
ENSPMAG00000005184	rnf113a	92	78.148	ENSORLG00000002442	rnf113a	84	78.148	Oryzias_latipes
ENSPMAG00000005184	rnf113a	92	78.519	ENSORLG00020011512	rnf113a	84	78.519	Oryzias_latipes_hni
ENSPMAG00000005184	rnf113a	92	78.148	ENSORLG00015004382	rnf113a	84	78.148	Oryzias_latipes_hsok
ENSPMAG00000005184	rnf113a	92	78.148	ENSOMEG00000020197	rnf113a	84	78.148	Oryzias_melastigma
ENSPMAG00000005184	rnf113a	98	67.347	ENSOGAG00000011638	RNF113B	86	67.347	Otolemur_garnettii
ENSPMAG00000005184	rnf113a	95	69.896	ENSOGAG00000031602	RNF113A	87	69.231	Otolemur_garnettii
ENSPMAG00000005184	rnf113a	95	68.276	ENSOARG00000009771	-	87	69.024	Ovis_aries
ENSPMAG00000005184	rnf113a	97	64.948	ENSOARG00000015294	-	85	64.966	Ovis_aries
ENSPMAG00000005184	rnf113a	94	59.273	ENSPPAG00000040641	RNF113B	84	59.273	Pan_paniscus
ENSPMAG00000005184	rnf113a	99	68.333	ENSPPAG00000009537	RNF113A	87	69.024	Pan_paniscus
ENSPMAG00000005184	rnf113a	95	69.550	ENSPPRG00000011512	-	86	69.595	Panthera_pardus
ENSPMAG00000005184	rnf113a	95	68.056	ENSPPRG00000020640	-	86	67.458	Panthera_pardus
ENSPMAG00000005184	rnf113a	95	69.550	ENSPTIG00000007986	-	86	69.595	Panthera_tigris_altaica
ENSPMAG00000005184	rnf113a	99	68.333	ENSPTRG00000022231	RNF113A	87	69.024	Pan_troglodytes
ENSPMAG00000005184	rnf113a	94	59.273	ENSPTRG00000005987	RNF113B	84	59.273	Pan_troglodytes
ENSPMAG00000005184	rnf113a	98	69.178	ENSPANG00000011522	RNF113A	85	69.521	Papio_anubis
ENSPMAG00000005184	rnf113a	94	75.636	ENSPKIG00000016796	rnf113a	86	76.895	Paramormyrops_kingsleyae
ENSPMAG00000005184	rnf113a	93	75.273	ENSPSIG00000012676	-	95	75.273	Pelodiscus_sinensis
ENSPMAG00000005184	rnf113a	92	78.889	ENSPMGG00000009668	rnf113a	84	78.889	Periophthalmus_magnuspinnatus
ENSPMAG00000005184	rnf113a	93	71.223	ENSPEMG00000002490	Rnf113a1	83	70.526	Peromyscus_maniculatus_bairdii
ENSPMAG00000005184	rnf113a	96	70.205	ENSPCIG00000028916	-	84	70.169	Phascolarctos_cinereus
ENSPMAG00000005184	rnf113a	92	78.519	ENSPFOG00000014248	rnf113a	84	78.519	Poecilia_formosa
ENSPMAG00000005184	rnf113a	92	78.519	ENSPLAG00000010435	rnf113a	84	78.519	Poecilia_latipinna
ENSPMAG00000005184	rnf113a	92	78.519	ENSPMEG00000010641	rnf113a	84	78.519	Poecilia_mexicana
ENSPMAG00000005184	rnf113a	92	78.519	ENSPREG00000009900	rnf113a	84	78.519	Poecilia_reticulata
ENSPMAG00000005184	rnf113a	99	68.333	ENSPPYG00000020676	RNF113A	87	69.697	Pongo_abelii
ENSPMAG00000005184	rnf113a	83	65.306	ENSPPYG00000005460	RNF113B	85	61.372	Pongo_abelii
ENSPMAG00000005184	rnf113a	93	71.480	ENSPCAG00000014633	-	83	71.831	Procavia_capensis
ENSPMAG00000005184	rnf113a	96	65.517	ENSPCOG00000005671	-	84	66.096	Propithecus_coquereli
ENSPMAG00000005184	rnf113a	92	76.838	ENSPNYG00000013863	rnf113a	84	77.941	Pundamilia_nyererei
ENSPMAG00000005184	rnf113a	91	78.731	ENSPNAG00000017428	rnf113a	84	80.586	Pygocentrus_nattereri
ENSPMAG00000005184	rnf113a	95	70.280	ENSRNOG00000059412	Rnf113a1	86	69.625	Rattus_norvegicus
ENSPMAG00000005184	rnf113a	95	70.280	ENSRNOG00000034040	LOC108348079	86	69.625	Rattus_norvegicus
ENSPMAG00000005184	rnf113a	98	68.687	ENSRBIG00000017389	RNF113A	87	69.024	Rhinopithecus_bieti
ENSPMAG00000005184	rnf113a	77	67.699	ENSRBIG00000036094	RNF113B	84	60.000	Rhinopithecus_bieti
ENSPMAG00000005184	rnf113a	98	68.687	ENSRROG00000012149	RNF113A	87	69.024	Rhinopithecus_roxellana
ENSPMAG00000005184	rnf113a	77	67.257	ENSRROG00000045661	RNF113B	84	59.636	Rhinopithecus_roxellana
ENSPMAG00000005184	rnf113a	97	68.707	ENSSBOG00000017704	RNF113A	87	69.000	Saimiri_boliviensis_boliviensis
ENSPMAG00000005184	rnf113a	79	69.099	ENSSBOG00000029719	RNF113B	85	60.932	Saimiri_boliviensis_boliviensis
ENSPMAG00000005184	rnf113a	91	71.119	ENSSHAG00000008839	-	79	71.786	Sarcophilus_harrisii
ENSPMAG00000005184	rnf113a	93	76.838	ENSSFOG00015016567	rnf113a	84	76.838	Scleropages_formosus
ENSPMAG00000005184	rnf113a	90	79.245	ENSSMAG00000009235	rnf113a	84	80.515	Scophthalmus_maximus
ENSPMAG00000005184	rnf113a	92	78.229	ENSSDUG00000022244	rnf113a	84	79.121	Seriola_dumerili
ENSPMAG00000005184	rnf113a	92	78.229	ENSSLDG00000018582	rnf113a	84	79.121	Seriola_lalandi_dorsalis
ENSPMAG00000005184	rnf113a	93	71.119	ENSSARG00000010436	-	83	70.423	Sorex_araneus
ENSPMAG00000005184	rnf113a	93	74.368	ENSSPUG00000018786	-	77	74.368	Sphenodon_punctatus
ENSPMAG00000005184	rnf113a	92	78.229	ENSSPAG00000013187	rnf113a	84	78.598	Stegastes_partitus
ENSPMAG00000005184	rnf113a	95	65.979	ENSSSCG00000032973	-	86	65.772	Sus_scrofa
ENSPMAG00000005184	rnf113a	99	71.429	ENSTGUG00000001947	-	90	71.429	Taeniopygia_guttata
ENSPMAG00000005184	rnf113a	95	76.619	ENSTRUG00000011142	rnf113a	88	77.739	Takifugu_rubripes
ENSPMAG00000005184	rnf113a	95	76.157	ENSTNIG00000014938	rnf113a	85	78.182	Tetraodon_nigroviridis
ENSPMAG00000005184	rnf113a	97	67.918	ENSTBEG00000012687	-	87	68.562	Tupaia_belangeri
ENSPMAG00000005184	rnf113a	89	72.659	ENSUAMG00000024564	-	81	72.263	Ursus_americanus
ENSPMAG00000005184	rnf113a	95	68.858	ENSUMAG00000002167	-	89	68.581	Ursus_maritimus
ENSPMAG00000005184	rnf113a	98	65.000	ENSVPAG00000004521	-	96	65.000	Vicugna_pacos
ENSPMAG00000005184	rnf113a	95	68.027	ENSVVUG00000011662	-	86	68.439	Vulpes_vulpes
ENSPMAG00000005184	rnf113a	62	63.636	ENSVVUG00000004522	-	65	62.371	Vulpes_vulpes
ENSPMAG00000005184	rnf113a	95	74.648	ENSXETG00000002042	rnf113a	90	74.306	Xenopus_tropicalis
ENSPMAG00000005184	rnf113a	92	76.296	ENSXCOG00000017542	rnf113a	87	76.296	Xiphophorus_couchianus
ENSPMAG00000005184	rnf113a	92	78.519	ENSXMAG00000008169	rnf113a	84	78.519	Xiphophorus_maculatus