EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSPPYG00000019172 (Gene tree)
Gene ID: -
Gene Symbol: -
Alias: -
Full Name: -
Gene Type: protein_coding
Species: Pongo_abelii
Status: putative
Strand: Minus strand
Length: 1846 bases
Position: chr9:40324094-40325939
Accession: -
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSPPYP00000021481	KH_1	PF00013.29	3.6e-43	1	4
ENSPPYP00000021481	KH_1	PF00013.29	3.6e-43	2	4
ENSPPYP00000021481	KH_1	PF00013.29	3.6e-43	3	4
ENSPPYP00000021481	KH_1	PF00013.29	3.6e-43	4	4
ENSPPYP00000021481	DUF1897	PF09005.10	5.6e-09	1	2
ENSPPYP00000021481	DUF1897	PF09005.10	5.6e-09	2	2

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSPPYT00000022353	-	1797	-	ENSPPYP00000021481	599 (aa)	-	H2PS15

Gene Model

Click here to download ENSPPYG00000019172's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSPPYG00000019172's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSPPYG00000019172	-	96	43.508	ENSPPYG00000019693	FUBP3	94	43.866
ENSPPYG00000019172	-	90	76.430	ENSPPYG00000009454	KHSRP	90	79.861
ENSPPYG00000019172	-	68	59.466	ENSPPYG00000001219	-	61	60.337

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSPPYG00000019172	-	95	76.771	ENSG00000088247	KHSRP	100	86.391	Homo_sapiens
ENSPPYG00000019172	-	85	56.915	ENSAPOG00000009524	khsrp	94	59.683	Acanthochromis_polyacanthus
ENSPPYG00000019172	-	95	57.254	ENSAPOG00000012989	KHSRP	91	60.669	Acanthochromis_polyacanthus
ENSPPYG00000019172	-	95	73.970	ENSAMEG00000006978	KHSRP	92	77.036	Ailuropoda_melanoleuca
ENSPPYG00000019172	-	95	52.848	ENSACIG00000009298	khsrp	94	55.956	Amphilophus_citrinellus
ENSPPYG00000019172	-	95	57.566	ENSAOCG00000010189	KHSRP	89	64.454	Amphiprion_ocellaris
ENSPPYG00000019172	-	95	54.984	ENSAOCG00000010049	khsrp	93	58.280	Amphiprion_ocellaris
ENSPPYG00000019172	-	95	57.566	ENSAPEG00000008575	KHSRP	91	60.987	Amphiprion_percula
ENSPPYG00000019172	-	95	54.984	ENSAPEG00000013411	khsrp	93	58.280	Amphiprion_percula
ENSPPYG00000019172	-	95	55.644	ENSATEG00000019332	khsrp	93	56.598	Anabas_testudineus
ENSPPYG00000019172	-	99	55.151	ENSATEG00000024744	KHSRP	93	56.894	Anabas_testudineus
ENSPPYG00000019172	-	95	71.732	ENSACAG00000015398	KHSRP	88	74.757	Anolis_carolinensis
ENSPPYG00000019172	-	93	70.847	ENSANAG00000027617	KHSRP	82	71.549	Aotus_nancymaae
ENSPPYG00000019172	-	92	58.981	ENSANAG00000004931	-	92	52.558	Aotus_nancymaae
ENSPPYG00000019172	-	95	56.656	ENSACLG00000001424	KHSRP	85	58.842	Astatotilapia_calliptera
ENSPPYG00000019172	-	96	55.591	ENSAMXG00000036582	khsrp	92	58.540	Astyanax_mexicanus
ENSPPYG00000019172	-	95	76.277	ENSBTAG00000021018	KHSRP	87	79.479	Bos_taurus
ENSPPYG00000019172	-	68	58.981	ENSBTAG00000008926	FUBP1	92	54.213	Bos_taurus
ENSPPYG00000019172	-	95	76.771	ENSCJAG00000016627	KHSRP	86	80.130	Callithrix_jacchus
ENSPPYG00000019172	-	85	73.945	ENSCAFG00000018667	KHSRP	92	78.623	Canis_familiaris
ENSPPYG00000019172	-	95	71.711	ENSCAFG00020019133	KHSRP	92	78.623	Canis_lupus_dingo
ENSPPYG00000019172	-	92	55.991	ENSCAFG00020015251	-	92	54.286	Canis_lupus_dingo
ENSPPYG00000019172	-	95	76.277	ENSCHIG00000027053	KHSRP	86	79.479	Capra_hircus
ENSPPYG00000019172	-	68	58.838	ENSCHIG00000013418	-	92	54.127	Capra_hircus
ENSPPYG00000019172	-	95	76.898	ENSTSYG00000011552	KHSRP	86	80.098	Carlito_syrichta
ENSPPYG00000019172	-	79	69.020	ENSCAPG00000005534	KHSRP	84	73.333	Cavia_aperea
ENSPPYG00000019172	-	95	76.033	ENSCPOG00000005140	KHSRP	84	79.085	Cavia_porcellus
ENSPPYG00000019172	-	95	71.122	ENSCCAG00000025297	KHSRP	86	76.672	Cebus_capucinus
ENSPPYG00000019172	-	89	81.994	ENSCATG00000036458	KHSRP	89	79.225	Cercocebus_atys
ENSPPYG00000019172	-	95	71.523	ENSCLAG00000007309	KHSRP	84	74.468	Chinchilla_lanigera
ENSPPYG00000019172	-	95	76.771	ENSCSAG00000009626	KHSRP	82	80.130	Chlorocebus_sabaeus
ENSPPYG00000019172	-	95	72.712	ENSCPBG00000005286	KHSRP	88	76.699	Chrysemys_picta_bellii
ENSPPYG00000019172	-	77	61.404	ENSCPBG00000016987	-	92	54.186	Chrysemys_picta_bellii
ENSPPYG00000019172	-	96	74.098	ENSCANG00000015665	KHSRP	93	77.833	Colobus_angolensis_palliatus
ENSPPYG00000019172	-	92	59.080	ENSCANG00000034534	-	92	52.868	Colobus_angolensis_palliatus
ENSPPYG00000019172	-	95	75.822	ENSCGRG00001011031	Khsrp	85	78.990	Cricetulus_griseus_chok1gshd
ENSPPYG00000019172	-	90	73.611	ENSCGRG00000015331	Khsrp	85	76.844	Cricetulus_griseus_crigri
ENSPPYG00000019172	-	96	49.296	ENSCSEG00000011429	khsrp	95	52.866	Cynoglossus_semilaevis
ENSPPYG00000019172	-	95	53.280	ENSCVAG00000001873	khsrp	95	55.502	Cyprinodon_variegatus
ENSPPYG00000019172	-	95	55.641	ENSDARG00000026489	khsrp	95	58.779	Danio_rerio
ENSPPYG00000019172	-	95	76.442	ENSDNOG00000046507	KHSRP	82	79.805	Dasypus_novemcinctus
ENSPPYG00000019172	-	68	58.838	ENSDNOG00000013200	-	92	54.114	Dasypus_novemcinctus
ENSPPYG00000019172	-	95	68.330	ENSDORG00000002447	Khsrp	86	71.892	Dipodomys_ordii
ENSPPYG00000019172	-	93	68.013	ENSETEG00000004793	KHSRP	90	70.707	Echinops_telfairi
ENSPPYG00000019172	-	95	76.442	ENSEASG00005023114	KHSRP	86	79.642	Equus_asinus_asinus
ENSPPYG00000019172	-	92	58.838	ENSEASG00005016990	-	92	54.127	Equus_asinus_asinus
ENSPPYG00000019172	-	95	76.442	ENSECAG00000018305	KHSRP	86	79.642	Equus_caballus
ENSPPYG00000019172	-	92	58.838	ENSECAG00000010867	FUBP1	92	54.286	Equus_caballus
ENSPPYG00000019172	-	69	70.674	ENSELUG00000016310	khsrp	94	58.218	Esox_lucius
ENSPPYG00000019172	-	95	56.132	ENSELUG00000008445	-	91	58.824	Esox_lucius
ENSPPYG00000019172	-	92	58.981	ENSFCAG00000010330	-	92	54.372	Felis_catus
ENSPPYG00000019172	-	95	75.618	ENSFCAG00000003731	KHSRP	86	79.805	Felis_catus
ENSPPYG00000019172	-	77	58.635	ENSFDAG00000010889	KHSRP	88	59.057	Fukomys_damarensis
ENSPPYG00000019172	-	69	60.563	ENSFHEG00000009577	khsrp	93	53.270	Fundulus_heteroclitus
ENSPPYG00000019172	-	95	53.686	ENSGMOG00000002166	khsrp	89	55.659	Gadus_morhua
ENSPPYG00000019172	-	95	51.104	ENSGAFG00000010469	khsrp	93	55.233	Gambusia_affinis
ENSPPYG00000019172	-	91	54.774	ENSGACG00000018990	khsrp	85	57.120	Gasterosteus_aculeatus
ENSPPYG00000019172	-	95	58.039	ENSGACG00000012422	KHSRP	92	59.003	Gasterosteus_aculeatus
ENSPPYG00000019172	-	69	82.567	ENSGAGG00000023246	KHSRP	91	76.699	Gopherus_agassizii
ENSPPYG00000019172	-	77	61.404	ENSGAGG00000019219	-	92	54.186	Gopherus_agassizii
ENSPPYG00000019172	-	95	76.898	ENSGGOG00000007028	KHSRP	95	80.261	Gorilla_gorilla
ENSPPYG00000019172	-	92	59.080	ENSGGOG00000027554	FUBP1	92	52.739	Gorilla_gorilla
ENSPPYG00000019172	-	95	57.674	ENSHBUG00000014760	KHSRP	91	58.740	Haplochromis_burtoni
ENSPPYG00000019172	-	95	75.987	ENSHGLG00000013239	KHSRP	86	79.024	Heterocephalus_glaber_female
ENSPPYG00000019172	-	73	66.225	ENSHGLG00100000480	KHSRP	76	65.376	Heterocephalus_glaber_male
ENSPPYG00000019172	-	95	51.852	ENSHCOG00000020488	khsrp	94	53.456	Hippocampus_comes
ENSPPYG00000019172	-	91	54.290	ENSIPUG00000008034	khsrp	95	61.646	Ictalurus_punctatus
ENSPPYG00000019172	-	95	76.403	ENSSTOG00000002371	KHSRP	92	79.608	Ictidomys_tridecemlineatus
ENSPPYG00000019172	-	95	74.300	ENSJJAG00000006370	Khsrp	82	77.687	Jaculus_jaculus
ENSPPYG00000019172	-	95	55.145	ENSKMAG00000018579	khsrp	94	56.309	Kryptolebias_marmoratus
ENSPPYG00000019172	-	85	54.270	ENSLBEG00000005191	khsrp	96	59.717	Labrus_bergylta
ENSPPYG00000019172	-	68	58.354	ENSLACG00000012547	-	95	53.333	Latimeria_chalumnae
ENSPPYG00000019172	-	95	60.328	ENSLACG00000002072	KHSRP	88	62.316	Latimeria_chalumnae
ENSPPYG00000019172	-	96	59.157	ENSLOCG00000006229	khsrp	93	63.166	Lepisosteus_oculatus
ENSPPYG00000019172	-	95	74.384	ENSLAFG00000002426	KHSRP	98	75.777	Loxodonta_africana
ENSPPYG00000019172	-	94	76.628	ENSMFAG00000000292	KHSRP	94	80.261	Macaca_fascicularis
ENSPPYG00000019172	-	95	77.069	ENSMMUG00000005597	KHSRP	85	79.727	Macaca_mulatta
ENSPPYG00000019172	-	95	73.223	ENSMNEG00000036982	KHSRP	86	76.835	Macaca_nemestrina
ENSPPYG00000019172	-	92	59.080	ENSMLEG00000032973	-	97	52.167	Mandrillus_leucophaeus
ENSPPYG00000019172	-	95	76.898	ENSMLEG00000030501	KHSRP	98	80.261	Mandrillus_leucophaeus
ENSPPYG00000019172	-	95	55.357	ENSMAMG00000011746	khsrp	90	57.282	Mastacembelus_armatus
ENSPPYG00000019172	-	95	57.492	ENSMAMG00000023639	KHSRP	89	59.451	Mastacembelus_armatus
ENSPPYG00000019172	-	95	57.143	ENSMZEG00005011227	KHSRP	91	58.740	Maylandia_zebra
ENSPPYG00000019172	-	95	63.527	ENSMZEG00005022974	-	89	63.285	Maylandia_zebra
ENSPPYG00000019172	-	95	74.007	ENSMAUG00000018966	Khsrp	88	77.087	Mesocricetus_auratus
ENSPPYG00000019172	-	92	58.981	ENSMICG00000014463	-	90	52.640	Microcebus_murinus
ENSPPYG00000019172	-	95	73.970	ENSMICG00000007863	KHSRP	85	77.199	Microcebus_murinus
ENSPPYG00000019172	-	95	73.841	ENSMOCG00000018305	Khsrp	84	77.250	Microtus_ochrogaster
ENSPPYG00000019172	-	95	50.598	ENSMMOG00000005097	-	92	51.453	Mola_mola
ENSPPYG00000019172	-	53	52.041	ENSMMOG00000021381	-	86	52.041	Mola_mola
ENSPPYG00000019172	-	95	72.323	ENSMODG00000001952	KHSRP	93	75.733	Monodelphis_domestica
ENSPPYG00000019172	-	95	48.112	ENSMALG00000006104	khsrp	94	50.796	Monopterus_albus
ENSPPYG00000019172	-	95	56.678	ENSMALG00000004958	KHSRP	86	56.418	Monopterus_albus
ENSPPYG00000019172	-	95	69.722	MGP_CAROLIEiJ_G0021800	Khsrp	82	71.845	Mus_caroli
ENSPPYG00000019172	-	95	75.618	ENSMUSG00000007670	Khsrp	85	78.827	Mus_musculus
ENSPPYG00000019172	-	95	75.618	MGP_PahariEiJ_G0020789	Khsrp	82	78.827	Mus_pahari
ENSPPYG00000019172	-	95	75.618	MGP_SPRETEiJ_G0022711	Khsrp	82	78.827	Mus_spretus
ENSPPYG00000019172	-	95	76.033	ENSMPUG00000006615	KHSRP	89	80.065	Mustela_putorius_furo
ENSPPYG00000019172	-	68	58.981	ENSMPUG00000010799	-	89	54.372	Mustela_putorius_furo
ENSPPYG00000019172	-	95	76.403	ENSMLUG00000015543	KHSRP	92	79.772	Myotis_lucifugus
ENSPPYG00000019172	-	95	74.300	ENSNGAG00000023093	Khsrp	82	78.013	Nannospalax_galili
ENSPPYG00000019172	-	95	52.581	ENSNBRG00000023797	khsrp	91	56.006	Neolamprologus_brichardi
ENSPPYG00000019172	-	95	57.050	ENSNBRG00000005876	KHSRP	89	59.325	Neolamprologus_brichardi
ENSPPYG00000019172	-	95	72.351	ENSNLEG00000015923	KHSRP	91	74.493	Nomascus_leucogenys
ENSPPYG00000019172	-	78	71.287	ENSMEUG00000016601	KHSRP	86	74.653	Notamacropus_eugenii
ENSPPYG00000019172	-	89	75.175	ENSOPRG00000010594	-	79	78.103	Ochotona_princeps
ENSPPYG00000019172	-	95	69.167	ENSODEG00000015021	KHSRP	87	71.570	Octodon_degus
ENSPPYG00000019172	-	92	54.474	ENSONIG00000002163	KHSRP	91	58.713	Oreochromis_niloticus
ENSPPYG00000019172	-	95	54.864	ENSONIG00000017713	khsrp	94	56.240	Oreochromis_niloticus
ENSPPYG00000019172	-	89	68.912	ENSOANG00000000261	KHSRP	91	72.884	Ornithorhynchus_anatinus
ENSPPYG00000019172	-	69	86.207	ENSOCUG00000026747	-	98	84.894	Oryctolagus_cuniculus
ENSPPYG00000019172	-	68	56.174	ENSOCUG00000002225	-	93	52.623	Oryctolagus_cuniculus
ENSPPYG00000019172	-	95	50.158	ENSORLG00000011882	khsrp	91	53.407	Oryzias_latipes
ENSPPYG00000019172	-	95	49.519	ENSORLG00020005284	khsrp	91	52.648	Oryzias_latipes_hni
ENSPPYG00000019172	-	95	51.954	ENSORLG00015003791	khsrp	93	54.823	Oryzias_latipes_hsok
ENSPPYG00000019172	-	92	50.656	ENSOMEG00000013233	khsrp	93	54.428	Oryzias_melastigma
ENSPPYG00000019172	-	95	76.606	ENSOGAG00000008073	KHSRP	86	79.967	Otolemur_garnettii
ENSPPYG00000019172	-	75	76.446	ENSOARG00000005881	KHSRP	97	79.959	Ovis_aries
ENSPPYG00000019172	-	92	59.080	ENSPPAG00000038243	-	92	52.322	Pan_paniscus
ENSPPYG00000019172	-	94	76.667	ENSPPAG00000036395	-	92	80.066	Pan_paniscus
ENSPPYG00000019172	-	91	73.077	ENSPPAG00000036398	-	94	77.329	Pan_paniscus
ENSPPYG00000019172	-	89	69.153	ENSPPRG00000008001	KHSRP	81	73.254	Panthera_pardus
ENSPPYG00000019172	-	92	59.080	ENSPTRG00000000888	FUBP1	92	52.403	Pan_troglodytes
ENSPPYG00000019172	-	95	74.877	ENSPTRG00000010364	KHSRP	85	76.221	Pan_troglodytes
ENSPPYG00000019172	-	92	59.223	ENSPANG00000004797	-	92	53.416	Papio_anubis
ENSPPYG00000019172	-	95	76.771	ENSPANG00000000103	KHSRP	86	80.130	Papio_anubis
ENSPPYG00000019172	-	77	62.745	ENSPKIG00000009065	-	93	49.042	Paramormyrops_kingsleyae
ENSPPYG00000019172	-	97	56.677	ENSPKIG00000005077	KHSRP	92	59.385	Paramormyrops_kingsleyae
ENSPPYG00000019172	-	96	65.625	ENSPKIG00000003200	khsrp	85	55.659	Paramormyrops_kingsleyae
ENSPPYG00000019172	-	69	82.082	ENSPSIG00000008244	KHSRP	96	64.239	Pelodiscus_sinensis
ENSPPYG00000019172	-	85	50.642	ENSPMGG00000016443	khsrp	94	52.190	Periophthalmus_magnuspinnatus
ENSPPYG00000019172	-	95	71.545	ENSPEMG00000022853	Khsrp	88	76.759	Peromyscus_maniculatus_bairdii
ENSPPYG00000019172	-	95	75.822	ENSPCIG00000025516	KHSRP	86	79.153	Phascolarctos_cinereus
ENSPPYG00000019172	-	92	59.662	ENSPCIG00000022984	-	92	53.895	Phascolarctos_cinereus
ENSPPYG00000019172	-	95	51.664	ENSPFOG00000004577	khsrp	93	55.968	Poecilia_formosa
ENSPPYG00000019172	-	91	50.889	ENSPLAG00000010763	khsrp	93	55.968	Poecilia_latipinna
ENSPPYG00000019172	-	91	50.889	ENSPMEG00000014049	khsrp	93	55.968	Poecilia_mexicana
ENSPPYG00000019172	-	91	50.484	ENSPREG00000000419	khsrp	93	55.878	Poecilia_reticulata
ENSPPYG00000019172	-	73	67.653	ENSPCAG00000000246	KHSRP	83	71.550	Procavia_capensis
ENSPPYG00000019172	-	94	76.461	ENSPCOG00000027506	KHSRP	94	79.935	Propithecus_coquereli
ENSPPYG00000019172	-	89	75.958	ENSPVAG00000007251	KHSRP	81	79.483	Pteropus_vampyrus
ENSPPYG00000019172	-	95	56.981	ENSPNYG00000014008	KHSRP	86	58.173	Pundamilia_nyererei
ENSPPYG00000019172	-	95	56.121	ENSPNAG00000012026	khsrp	92	59.091	Pygocentrus_nattereri
ENSPPYG00000019172	-	95	75.618	ENSRNOG00000047628	Khsrp	85	78.827	Rattus_norvegicus
ENSPPYG00000019172	-	94	69.551	ENSRBIG00000041605	KHSRP	97	72.504	Rhinopithecus_bieti
ENSPPYG00000019172	-	95	76.771	ENSRROG00000031782	KHSRP	86	80.130	Rhinopithecus_roxellana
ENSPPYG00000019172	-	95	76.898	ENSSBOG00000034871	KHSRP	98	80.261	Saimiri_boliviensis_boliviensis
ENSPPYG00000019172	-	92	75.298	ENSSHAG00000011383	KHSRP	92	78.788	Sarcophilus_harrisii
ENSPPYG00000019172	-	97	56.309	ENSSFOG00015010767	KHSRP	92	59.472	Scleropages_formosus
ENSPPYG00000019172	-	95	52.472	ENSSFOG00015018719	khsrp	92	56.825	Scleropages_formosus
ENSPPYG00000019172	-	95	50.769	ENSSMAG00000004167	khsrp	94	55.431	Scophthalmus_maximus
ENSPPYG00000019172	-	95	53.810	ENSSDUG00000002390	khsrp	93	57.638	Seriola_dumerili
ENSPPYG00000019172	-	95	58.214	ENSSDUG00000002110	KHSRP	91	60.254	Seriola_dumerili
ENSPPYG00000019172	-	95	58.214	ENSSLDG00000025625	KHSRP	91	60.095	Seriola_lalandi_dorsalis
ENSPPYG00000019172	-	95	51.424	ENSSLDG00000012993	khsrp	94	54.198	Seriola_lalandi_dorsalis
ENSPPYG00000019172	-	68	80.676	ENSSPUG00000016462	KHSRP	92	74.799	Sphenodon_punctatus
ENSPPYG00000019172	-	97	57.600	ENSSPAG00000008244	KHSRP	83	60.287	Stegastes_partitus
ENSPPYG00000019172	-	95	53.920	ENSSPAG00000008349	khsrp	93	57.369	Stegastes_partitus
ENSPPYG00000019172	-	68	58.981	ENSSSCG00000003771	-	97	52.105	Sus_scrofa
ENSPPYG00000019172	-	95	76.442	ENSSSCG00000013538	KHSRP	92	78.442	Sus_scrofa
ENSPPYG00000019172	-	92	50.408	ENSTNIG00000014067	khsrp	93	53.659	Tetraodon_nigroviridis
ENSPPYG00000019172	-	93	73.746	ENSTTRG00000010390	KHSRP	84	76.756	Tursiops_truncatus
ENSPPYG00000019172	-	92	57.767	ENSUAMG00000004961	-	96	54.545	Ursus_americanus
ENSPPYG00000019172	-	84	72.897	ENSUAMG00000023100	KHSRP	81	78.108	Ursus_americanus
ENSPPYG00000019172	-	95	68.699	ENSUMAG00000011144	KHSRP	86	73.127	Ursus_maritimus
ENSPPYG00000019172	-	92	58.838	ENSUMAG00000006022	-	92	52.535	Ursus_maritimus
ENSPPYG00000019172	-	62	79.387	ENSVPAG00000010837	-	100	79.387	Vicugna_pacos
ENSPPYG00000019172	-	96	58.838	ENSVVUG00000030003	-	92	52.615	Vulpes_vulpes
ENSPPYG00000019172	-	95	71.782	ENSVVUG00000026737	KHSRP	92	78.623	Vulpes_vulpes
ENSPPYG00000019172	-	92	58.475	ENSXETG00000021862	khsrp	98	59.231	Xenopus_tropicalis
ENSPPYG00000019172	-	68	58.454	ENSXETG00000013137	fubp1	93	54.041	Xenopus_tropicalis
ENSPPYG00000019172	-	95	51.510	ENSXCOG00000014443	khsrp	89	55.806	Xiphophorus_couchianus
ENSPPYG00000019172	-	95	51.177	ENSXMAG00000012876	khsrp	93	55.556	Xiphophorus_maculatus