EuRBPDB

Description

RBDs

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSRNOG00000048315 (Gene tree)
Gene ID: 54287
Gene Symbol: Eif2ak2
Alias: Pkr|Prkr
Full Name: eukaryotic translation initiation factor 2-alpha kinase 2
Gene Type: protein_coding
Species: Rattus_norvegicus
Status: putative
Strand: Minus strand
Length: 37368 bases
Position: chr6:1428834-1466201
Accession: 3402
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSRNOP00000067694	dsrm	PF00035.26	4.1e-34	1	2
ENSRNOP00000067694	dsrm	PF00035.26	4.1e-34	2	2
ENSRNOP00000071646	dsrm	PF00035.26	4.1e-34	1	2
ENSRNOP00000071646	dsrm	PF00035.26	4.1e-34	2	2

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSRNOT00000089185	-	3827	XM_008764426	ENSRNOP00000071646	513 (aa)	XP_008762648	M0RDJ3
ENSRNOT00000072810	-	1542	XM_008764425	ENSRNOP00000067694	513 (aa)	XP_008762647	M0RDJ3

Gene Model

Click here to download ENSRNOG00000048315's gene model file

Pathways

Pathway ID	Pathway Name	Source
rno04141	Protein processing in endoplasmic reticulum	KEGG
rno04217	Necroptosis	KEGG
rno05160	Hepatitis C	KEGG
rno05162	Measles	KEGG
rno05164	Influenza A	KEGG
rno05165	Human papillomavirus infection	KEGG
rno05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
rno05168	Herpes simplex virus 1 infection	KEGG
rno05169	Epstein-Barr virus infection	KEGG
rno05203	Viral carcinogenesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSRNOG00000048315's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSRNOG00000048315	Eif2ak2	100	57.554	ENSG00000055332	EIF2AK2	100	59.804	Homo_sapiens
ENSRNOG00000048315	Eif2ak2	98	34.864	ENSAPOG00000010686	-	80	42.951	Acanthochromis_polyacanthus
ENSRNOG00000048315	Eif2ak2	100	50.802	ENSAMEG00000017552	EIF2AK2	100	51.159	Ailuropoda_melanoleuca
ENSRNOG00000048315	Eif2ak2	97	35.874	ENSAOCG00000003388	-	97	35.688	Amphiprion_ocellaris
ENSRNOG00000048315	Eif2ak2	99	34.409	ENSAOCG00000003368	-	99	34.783	Amphiprion_ocellaris
ENSRNOG00000048315	Eif2ak2	97	34.790	ENSAPEG00000023903	-	83	44.178	Amphiprion_percula
ENSRNOG00000048315	Eif2ak2	99	34.861	ENSAPEG00000023919	-	88	34.783	Amphiprion_percula
ENSRNOG00000048315	Eif2ak2	96	36.679	ENSACAG00000008379	EIF2AK2	97	35.766	Anolis_carolinensis
ENSRNOG00000048315	Eif2ak2	99	54.215	ENSANAG00000035319	EIF2AK2	100	54.215	Aotus_nancymaae
ENSRNOG00000048315	Eif2ak2	96	33.453	ENSACLG00000023938	-	97	33.092	Astatotilapia_calliptera
ENSRNOG00000048315	Eif2ak2	98	33.696	ENSACLG00000023699	-	98	32.790	Astatotilapia_calliptera
ENSRNOG00000048315	Eif2ak2	99	52.799	ENSBTAG00000008703	EIF2AK2	99	52.593	Bos_taurus
ENSRNOG00000048315	Eif2ak2	99	56.373	ENSCJAG00000003819	EIF2AK2	99	56.014	Callithrix_jacchus
ENSRNOG00000048315	Eif2ak2	98	54.887	ENSCAFG00000006051	EIF2AK2	98	54.887	Canis_familiaris
ENSRNOG00000048315	Eif2ak2	98	54.887	ENSCAFG00020022842	EIF2AK2	98	54.887	Canis_lupus_dingo
ENSRNOG00000048315	Eif2ak2	99	51.111	ENSCHIG00000016319	EIF2AK2	99	51.977	Capra_hircus
ENSRNOG00000048315	Eif2ak2	99	53.102	ENSTSYG00000013328	EIF2AK2	99	54.579	Carlito_syrichta
ENSRNOG00000048315	Eif2ak2	99	50.575	ENSCAPG00000016388	-	99	50.958	Cavia_aperea
ENSRNOG00000048315	Eif2ak2	99	51.024	ENSCPOG00000012198	EIF2AK2	99	51.210	Cavia_porcellus
ENSRNOG00000048315	Eif2ak2	99	58.349	ENSCCAG00000037822	EIF2AK2	99	57.707	Cebus_capucinus
ENSRNOG00000048315	Eif2ak2	99	54.562	ENSCATG00000036727	EIF2AK2	99	53.818	Cercocebus_atys
ENSRNOG00000048315	Eif2ak2	83	55.333	ENSCLAG00000008409	-	99	55.481	Chinchilla_lanigera
ENSRNOG00000048315	Eif2ak2	100	55.495	ENSCSAG00000012135	EIF2AK2	99	54.955	Chlorocebus_sabaeus
ENSRNOG00000048315	Eif2ak2	73	68.354	ENSCHOG00000004388	-	70	68.354	Choloepus_hoffmanni
ENSRNOG00000048315	Eif2ak2	99	67.290	ENSCGRG00001021739	eIF2aK2	99	68.421	Cricetulus_griseus_chok1gshd
ENSRNOG00000048315	Eif2ak2	82	65.654	ENSCGRG00000015847	Eif2ak2	99	64.944	Cricetulus_griseus_crigri
ENSRNOG00000048315	Eif2ak2	99	52.930	ENSDNOG00000010498	EIF2AK2	99	52.747	Dasypus_novemcinctus
ENSRNOG00000048315	Eif2ak2	99	55.837	ENSDORG00000009488	Eif2ak2	100	55.922	Dipodomys_ordii
ENSRNOG00000048315	Eif2ak2	87	59.124	ENSETEG00000009782	-	75	50.289	Echinops_telfairi
ENSRNOG00000048315	Eif2ak2	99	53.626	ENSEASG00005007360	EIF2AK2	98	54.545	Equus_asinus_asinus
ENSRNOG00000048315	Eif2ak2	100	53.188	ENSECAG00000011726	EIF2AK2	100	53.370	Equus_caballus
ENSRNOG00000048315	Eif2ak2	58	50.676	ENSEEUG00000005539	-	65	67.500	Erinaceus_europaeus
ENSRNOG00000048315	Eif2ak2	99	53.591	ENSFCAG00000006339	EIF2AK2	99	53.591	Felis_catus
ENSRNOG00000048315	Eif2ak2	93	36.038	ENSFALG00000011889	EIF2AK2	77	44.867	Ficedula_albicollis
ENSRNOG00000048315	Eif2ak2	82	54.525	ENSFDAG00000006052	-	98	55.204	Fukomys_damarensis
ENSRNOG00000048315	Eif2ak2	95	36.716	ENSGALG00000010560	EIF2AK2	96	37.222	Gallus_gallus
ENSRNOG00000048315	Eif2ak2	93	38.571	ENSGAFG00000005269	-	96	38.571	Gambusia_affinis
ENSRNOG00000048315	Eif2ak2	95	42.672	ENSGAGG00000002104	EIF2AK2	96	42.385	Gopherus_agassizii
ENSRNOG00000048315	Eif2ak2	100	57.554	ENSGGOG00000005556	EIF2AK2	100	57.374	Gorilla_gorilla
ENSRNOG00000048315	Eif2ak2	99	55.762	ENSHGLG00000013093	EIF2AK2	99	55.493	Heterocephalus_glaber_female
ENSRNOG00000048315	Eif2ak2	99	55.576	ENSHGLG00100005051	EIF2AK2	99	55.307	Heterocephalus_glaber_male
ENSRNOG00000048315	Eif2ak2	99	57.380	ENSSTOG00000013886	EIF2AK2	99	57.778	Ictidomys_tridecemlineatus
ENSRNOG00000048315	Eif2ak2	99	51.341	ENSJJAG00000015000	-	99	50.969	Jaculus_jaculus
ENSRNOG00000048315	Eif2ak2	98	35.252	ENSKMAG00000008407	-	97	36.943	Kryptolebias_marmoratus
ENSRNOG00000048315	Eif2ak2	88	46.237	ENSLOCG00000015909	-	74	46.454	Lepisosteus_oculatus
ENSRNOG00000048315	Eif2ak2	100	55.766	ENSLAFG00000018604	EIF2AK2	100	56.274	Loxodonta_africana
ENSRNOG00000048315	Eif2ak2	98	53.721	ENSMFAG00000030576	EIF2AK2	98	53.467	Macaca_fascicularis
ENSRNOG00000048315	Eif2ak2	99	53.597	ENSMMUG00000037522	EIF2AK2	99	52.613	Macaca_mulatta
ENSRNOG00000048315	Eif2ak2	86	65.942	ENSMNEG00000040090	EIF2AK2	98	65.942	Macaca_nemestrina
ENSRNOG00000048315	Eif2ak2	99	52.482	ENSMLEG00000033494	EIF2AK2	99	53.091	Mandrillus_leucophaeus
ENSRNOG00000048315	Eif2ak2	96	37.838	ENSMZEG00005009747	-	81	37.838	Maylandia_zebra
ENSRNOG00000048315	Eif2ak2	96	36.347	ENSMGAG00000011175	EIF2AK2	96	37.201	Meleagris_gallopavo
ENSRNOG00000048315	Eif2ak2	99	66.472	ENSMAUG00000000309	Eif2ak2	99	66.472	Mesocricetus_auratus
ENSRNOG00000048315	Eif2ak2	99	53.430	ENSMICG00000003317	EIF2AK2	94	53.249	Microcebus_murinus
ENSRNOG00000048315	Eif2ak2	99	49.130	ENSMOCG00000021613	-	99	47.969	Microtus_ochrogaster
ENSRNOG00000048315	Eif2ak2	97	36.486	ENSMMOG00000000659	-	97	36.585	Mola_mola
ENSRNOG00000048315	Eif2ak2	98	46.845	ENSMODG00000015286	-	97	45.369	Monodelphis_domestica
ENSRNOG00000048315	Eif2ak2	100	67.115	MGP_CAROLIEiJ_G0021889	Eif2ak2	100	67.115	Mus_caroli
ENSRNOG00000048315	Eif2ak2	100	76.538	ENSMUSG00000024079	Eif2ak2	100	76.538	Mus_musculus
ENSRNOG00000048315	Eif2ak2	100	77.586	MGP_PahariEiJ_G0020877	Eif2ak2	100	77.586	Mus_pahari
ENSRNOG00000048315	Eif2ak2	100	76.154	MGP_SPRETEiJ_G0022803	Eif2ak2	100	76.154	Mus_spretus
ENSRNOG00000048315	Eif2ak2	92	52.008	ENSMPUG00000009893	EIF2AK2	99	52.008	Mustela_putorius_furo
ENSRNOG00000048315	Eif2ak2	99	50.719	ENSMLUG00000003513	-	99	50.360	Myotis_lucifugus
ENSRNOG00000048315	Eif2ak2	84	44.760	ENSMLUG00000030615	-	99	46.070	Myotis_lucifugus
ENSRNOG00000048315	Eif2ak2	99	61.260	ENSNGAG00000017501	Eif2ak2	99	61.377	Nannospalax_galili
ENSRNOG00000048315	Eif2ak2	97	35.753	ENSNBRG00000019369	-	97	35.753	Neolamprologus_brichardi
ENSRNOG00000048315	Eif2ak2	99	51.521	ENSNLEG00000016201	EIF2AK2	99	51.887	Nomascus_leucogenys
ENSRNOG00000048315	Eif2ak2	88	47.647	ENSOPRG00000008168	-	88	47.647	Ochotona_princeps
ENSRNOG00000048315	Eif2ak2	98	42.545	ENSOANG00000003939	-	97	42.364	Ornithorhynchus_anatinus
ENSRNOG00000048315	Eif2ak2	99	53.091	ENSOCUG00000007223	EIF2AK2	99	53.261	Oryctolagus_cuniculus
ENSRNOG00000048315	Eif2ak2	100	54.919	ENSOGAG00000002562	EIF2AK2	100	54.919	Otolemur_garnettii
ENSRNOG00000048315	Eif2ak2	99	48.932	ENSOARG00000009740	EIF2AK2	99	48.399	Ovis_aries
ENSRNOG00000048315	Eif2ak2	100	57.014	ENSPPAG00000034727	EIF2AK2	100	56.835	Pan_paniscus
ENSRNOG00000048315	Eif2ak2	99	53.223	ENSPPRG00000003287	EIF2AK2	99	53.223	Panthera_pardus
ENSRNOG00000048315	Eif2ak2	99	53.407	ENSPTIG00000018329	EIF2AK2	99	53.407	Panthera_tigris_altaica
ENSRNOG00000048315	Eif2ak2	100	57.014	ENSPTRG00000011834	EIF2AK2	100	56.835	Pan_troglodytes
ENSRNOG00000048315	Eif2ak2	99	53.584	ENSPANG00000004770	EIF2AK2	99	54.069	Papio_anubis
ENSRNOG00000048315	Eif2ak2	97	40.142	ENSPSIG00000018049	EIF2AK2	98	40.853	Pelodiscus_sinensis
ENSRNOG00000048315	Eif2ak2	82	64.286	ENSPEMG00000010269	Eif2ak2	100	62.824	Peromyscus_maniculatus_bairdii
ENSRNOG00000048315	Eif2ak2	97	43.670	ENSPCIG00000010984	-	97	45.181	Phascolarctos_cinereus
ENSRNOG00000048315	Eif2ak2	83	35.535	ENSPLAG00000023907	-	97	32.096	Poecilia_latipinna
ENSRNOG00000048315	Eif2ak2	97	41.176	ENSPREG00000007871	-	97	41.250	Poecilia_reticulata
ENSRNOG00000048315	Eif2ak2	100	51.619	ENSPPYG00000012493	EIF2AK2	100	51.543	Pongo_abelii
ENSRNOG00000048315	Eif2ak2	84	62.500	ENSPCAG00000013068	EIF2AK2	75	62.500	Procavia_capensis
ENSRNOG00000048315	Eif2ak2	99	55.696	ENSPCOG00000014117	EIF2AK2	99	55.515	Propithecus_coquereli
ENSRNOG00000048315	Eif2ak2	100	53.663	ENSPVAG00000013831	EIF2AK2	100	52.747	Pteropus_vampyrus
ENSRNOG00000048315	Eif2ak2	100	53.571	ENSRBIG00000034494	EIF2AK2	100	54.710	Rhinopithecus_bieti
ENSRNOG00000048315	Eif2ak2	100	55.240	ENSRROG00000040152	EIF2AK2	100	55.315	Rhinopithecus_roxellana
ENSRNOG00000048315	Eif2ak2	99	54.775	ENSSBOG00000026743	EIF2AK2	99	54.710	Saimiri_boliviensis_boliviensis
ENSRNOG00000048315	Eif2ak2	96	41.026	ENSSHAG00000001447	-	96	41.308	Sarcophilus_harrisii
ENSRNOG00000048315	Eif2ak2	97	36.871	ENSSFOG00015008993	-	96	39.877	Scleropages_formosus
ENSRNOG00000048315	Eif2ak2	99	37.029	ENSSMAG00000010248	-	99	35.028	Scophthalmus_maximus
ENSRNOG00000048315	Eif2ak2	97	31.145	ENSSDUG00000002941	-	98	31.429	Seriola_dumerili
ENSRNOG00000048315	Eif2ak2	97	32.712	ENSSPAG00000007546	-	76	42.395	Stegastes_partitus
ENSRNOG00000048315	Eif2ak2	90	33.100	ENSSPAG00000007673	-	83	35.669	Stegastes_partitus
ENSRNOG00000048315	Eif2ak2	100	53.199	ENSSSCG00000008496	-	100	54.396	Sus_scrofa
ENSRNOG00000048315	Eif2ak2	96	36.182	ENSTGUG00000008788	EIF2AK2	97	36.364	Taeniopygia_guttata
ENSRNOG00000048315	Eif2ak2	96	33.922	ENSTRUG00000002791	-	97	34.185	Takifugu_rubripes
ENSRNOG00000048315	Eif2ak2	85	37.161	ENSTNIG00000000327	-	100	36.743	Tetraodon_nigroviridis
ENSRNOG00000048315	Eif2ak2	71	63.959	ENSTBEG00000014601	-	66	63.959	Tupaia_belangeri
ENSRNOG00000048315	Eif2ak2	100	54.396	ENSTTRG00000006882	EIF2AK2	100	54.396	Tursiops_truncatus
ENSRNOG00000048315	Eif2ak2	84	54.483	ENSUAMG00000015141	-	97	53.687	Ursus_americanus
ENSRNOG00000048315	Eif2ak2	100	51.818	ENSUMAG00000014765	EIF2AK2	100	51.818	Ursus_maritimus
ENSRNOG00000048315	Eif2ak2	99	56.089	ENSVPAG00000003303	EIF2AK2	99	55.823	Vicugna_pacos
ENSRNOG00000048315	Eif2ak2	99	55.243	ENSVVUG00000018911	EIF2AK2	99	55.243	Vulpes_vulpes
ENSRNOG00000048315	Eif2ak2	85	36.986	ENSXETG00000025302	eif2ak2	93	36.986	Xenopus_tropicalis
ENSRNOG00000048315	Eif2ak2	97	38.824	ENSXCOG00000006974	-	96	34.522	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000186	activation of MAPKK activity	-	IEA	Process
GO:0000186	activation of MAPKK activity	-	ISO	Process
GO:0000186	activation of MAPKK activity	-	ISS	Process
GO:0001819	positive regulation of cytokine production	-	ISO	Process
GO:0001819	positive regulation of cytokine production	-	ISS	Process
GO:0003725	double-stranded RNA binding	-	IEA	Function
GO:0003725	double-stranded RNA binding	-	ISO	Function
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004672	protein kinase activity	-	ISO	Function
GO:0004672	protein kinase activity	-	ISS	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	21873635.	IBA	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	-	IEA	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	-	ISO	Function
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IEA	Function
GO:0005515	protein binding	17953670.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	17953670.	IDA	Component
GO:0005737	cytoplasm	-	ISO	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005829	cytosol	-	IEA	Component
GO:0005829	cytosol	-	ISO	Component
GO:0006412	translation	-	ISO	Process
GO:0006468	protein phosphorylation	-	ISO	Process
GO:0006468	protein phosphorylation	-	ISS	Process
GO:0009612	response to mechanical stimulus	15781241.	IEP	Process
GO:0009615	response to virus	-	IEA	Process
GO:0009615	response to virus	-	ISO	Process
GO:0009615	response to virus	-	ISS	Process
GO:0009636	response to toxic substance	-	IEA	Process
GO:0009636	response to toxic substance	18535002.	IMP	Process
GO:0010033	response to organic substance	17761171.	IEP	Process
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	-	IEA	Process
GO:0017148	negative regulation of translation	-	IEA	Process
GO:0017148	negative regulation of translation	-	ISO	Process
GO:0017148	negative regulation of translation	-	ISS	Process
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	Process
GO:0022626	cytosolic ribosome	21873635.	IBA	Component
GO:0030968	endoplasmic reticulum unfolded protein response	-	ISO	Process
GO:0032496	response to lipopolysaccharide	15630703.	IMP	Process
GO:0032722	positive regulation of chemokine production	-	ISO	Process
GO:0032722	positive regulation of chemokine production	-	ISS	Process
GO:0032874	positive regulation of stress-activated MAPK cascade	-	ISO	Process
GO:0032874	positive regulation of stress-activated MAPK cascade	-	ISS	Process
GO:0033197	response to vitamin E	17953670.	IPI	Process
GO:0033689	negative regulation of osteoblast proliferation	-	IEA	Process
GO:0033689	negative regulation of osteoblast proliferation	-	ISO	Process
GO:0033689	negative regulation of osteoblast proliferation	-	ISS	Process
GO:0034198	cellular response to amino acid starvation	-	IEA	Process
GO:0034198	cellular response to amino acid starvation	-	ISO	Process
GO:0035455	response to interferon-alpha	-	IEA	Process
GO:0035455	response to interferon-alpha	-	ISO	Process
GO:0035455	response to interferon-alpha	-	ISS	Process
GO:0042802	identical protein binding	-	IEA	Function
GO:0042802	identical protein binding	-	ISO	Function
GO:0042981	regulation of apoptotic process	-	IEA	Process
GO:0043065	positive regulation of apoptotic process	18535002.	IMP	Process
GO:0043066	negative regulation of apoptotic process	-	ISO	Process
GO:0043330	response to exogenous dsRNA	15920723.	IEP	Process
GO:0045071	negative regulation of viral genome replication	-	IEA	Process
GO:0045071	negative regulation of viral genome replication	-	ISO	Process
GO:0045071	negative regulation of viral genome replication	-	ISS	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0046777	protein autophosphorylation	-	IEA	Process
GO:0046777	protein autophosphorylation	-	ISO	Process
GO:0046777	protein autophosphorylation	-	ISS	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0048471	perinuclear region of cytoplasm	-	ISO	Component
GO:0048471	perinuclear region of cytoplasm	-	ISS	Component
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IEA	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	ISO	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	ISS	Process
GO:0051607	defense response to virus	-	IEA	Process
GO:1900225	regulation of NLRP3 inflammasome complex assembly	-	ISO	Process
GO:1900225	regulation of NLRP3 inflammasome complex assembly	-	ISS	Process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	ISO	Process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	ISS	Process
GO:1901532	regulation of hematopoietic progenitor cell differentiation	-	ISO	Process
GO:1901532	regulation of hematopoietic progenitor cell differentiation	-	ISS	Process
GO:1902033	regulation of hematopoietic stem cell proliferation	-	ISO	Process
GO:1902033	regulation of hematopoietic stem cell proliferation	-	ISS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	ISO	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	ISS	Process