EuRBPDB

Description

RBDs

RBPome

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: FBgn0002774 (Gene tree)
Gene ID: 35523
Gene Symbol: mle
Alias: -
Full Name: maleless
Gene Type: protein_coding
Species: Drosophila_melanogaster
Status: confidence
Strand: Minus strand
Length: 5922 bases
Position: chr2R:5974857-5980778
Accession: FBgn0002774
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
FBpp0085367	dsrm	PF00035.26	8.5e-17	1	1
FBpp0100031	DEAD	PF00270.29	2.5e-06	1	1
FBpp0085367	DEAD	PF00270.29	4.5e-06	1	1
FBpp0100031	HA2	PF04408.23	2e-13	1	1
FBpp0085367	HA2	PF04408.23	2.7e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27197210	The mRNA-bound proteome of the early fly embryo	IC & embryos	2016 Apr 28	Wessels HH	DOI: 10.1101/gr.200386.115

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
FBtr0100576	-	4023	-	FBpp0100031	936 (aa)	-	B3STG4
FBtr0086031	-	4062	-	FBpp0085367	1293 (aa)	-	P24785

Gene Model

Click here to download FBgn0002774's gene model file

Protein-Protein Interaction (PPI)

Clik here to download FBgn0002774's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
FBgn0002774	mle	64	42.268	FBgn0032194	CG4901	66	42.268
FBgn0002774	mle	79	31.316	FBgn0030833	CG8915	74	31.234
FBgn0002774	mle	76	36.795	FBgn0030246	CG1582	60	36.795
FBgn0002774	mle	58	33.274	FBgn0031631	CG3225	72	33.274
FBgn0002774	mle	76	34.516	FBgn0032883	Rhau	76	34.516
FBgn0002774	mle	56	38.144	FBgn0086444	l(2)37Cb	57	36.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
FBgn0002774	mle	88	54.227	ENSG00000135829	DHX9	93	50.617	Homo_sapiens
FBgn0002774	mle	88	54.106	ENSAMEG00000002233	DHX9	93	51.278	Ailuropoda_melanoleuca
FBgn0002774	mle	88	53.800	ENSACIG00000016431	dhx9	94	49.720	Amphilophus_citrinellus
FBgn0002774	mle	84	52.337	ENSAOCG00000010719	dhx9	98	52.968	Amphiprion_ocellaris
FBgn0002774	mle	88	55.260	ENSAPEG00000006339	dhx9	95	50.040	Amphiprion_percula
FBgn0002774	mle	88	55.018	ENSATEG00000007101	dhx9	99	51.771	Anabas_testudineus
FBgn0002774	mle	97	51.690	ENSANAG00000030279	DHX9	93	50.453	Aotus_nancymaae
FBgn0002774	mle	91	53.380	ENSACLG00000022296	dhx9	99	51.207	Astatotilapia_calliptera
FBgn0002774	mle	91	51.635	ENSBTAG00000019821	DHX9	92	51.693	Bos_taurus
FBgn0002774	mle	96	39.328	WBGene00004355	rha-1	88	40.921	Caenorhabditis_elegans
FBgn0002774	mle	96	51.766	ENSCJAG00000004821	DHX9	92	51.944	Callithrix_jacchus
FBgn0002774	mle	88	54.227	ENSCAFG00000013205	DHX9	93	51.349	Canis_familiaris
FBgn0002774	mle	88	54.227	ENSCAFG00020014886	DHX9	93	51.349	Canis_lupus_dingo
FBgn0002774	mle	91	50.419	ENSCHIG00000018643	DHX9	93	50.495	Capra_hircus
FBgn0002774	mle	88	54.172	ENSTSYG00000007970	DHX9	99	51.280	Carlito_syrichta
FBgn0002774	mle	80	53.903	ENSCAPG00000015604	DHX9	72	59.829	Cavia_aperea
FBgn0002774	mle	88	54.710	ENSCPOG00000040669	DHX9	86	51.144	Cavia_porcellus
FBgn0002774	mle	86	62.372	ENSCCAG00000022597	DHX9	92	53.944	Cebus_capucinus
FBgn0002774	mle	88	54.227	ENSCATG00000027871	DHX9	99	52.611	Cercocebus_atys
FBgn0002774	mle	88	54.589	ENSCLAG00000010684	DHX9	85	51.318	Chinchilla_lanigera
FBgn0002774	mle	88	54.227	ENSCSAG00000012549	DHX9	91	52.746	Chlorocebus_sabaeus
FBgn0002774	mle	89	44.369	ENSCHOG00000012736	DHX9	99	44.881	Choloepus_hoffmanni
FBgn0002774	mle	92	51.083	ENSCPBG00000015757	DHX9	94	50.659	Chrysemys_picta_bellii
FBgn0002774	mle	92	52.995	ENSCSAVG00000001493	-	99	52.909	Ciona_savignyi
FBgn0002774	mle	88	54.227	ENSCANG00000032888	DHX9	93	51.049	Colobus_angolensis_palliatus
FBgn0002774	mle	91	51.082	ENSCGRG00001015796	Dhx9	96	51.193	Cricetulus_griseus_chok1gshd
FBgn0002774	mle	91	51.082	ENSCGRG00000011336	Dhx9	96	49.054	Cricetulus_griseus_crigri
FBgn0002774	mle	89	51.119	ENSCSEG00000017621	dhx9	99	51.205	Cynoglossus_semilaevis
FBgn0002774	mle	88	54.414	ENSCVAG00000009479	dhx9	94	50.211	Cyprinodon_variegatus
FBgn0002774	mle	88	54.788	ENSDARG00000079725	dhx9	94	51.188	Danio_rerio
FBgn0002774	mle	92	50.248	ENSDNOG00000004038	DHX9	94	50.821	Dasypus_novemcinctus
FBgn0002774	mle	88	53.809	ENSDORG00000012610	Dhx9	86	50.905	Dipodomys_ordii
FBgn0002774	mle	77	62.500	ENSETEG00000009729	DHX9	76	62.500	Echinops_telfairi
FBgn0002774	mle	99	51.979	ENSEBUG00000015945	-	89	52.994	Eptatretus_burgeri
FBgn0002774	mle	88	54.106	ENSEASG00005006589	DHX9	92	51.027	Equus_asinus_asinus
FBgn0002774	mle	88	54.106	ENSECAG00000011933	DHX9	95	51.027	Equus_caballus
FBgn0002774	mle	79	53.081	ENSEEUG00000004824	DHX9	72	64.444	Erinaceus_europaeus
FBgn0002774	mle	88	54.655	ENSELUG00000010512	dhx9	94	50.568	Esox_lucius
FBgn0002774	mle	92	50.744	ENSFCAG00000019306	DHX9	94	51.017	Felis_catus
FBgn0002774	mle	88	54.897	ENSFALG00000002992	DHX9	95	51.443	Ficedula_albicollis
FBgn0002774	mle	88	54.469	ENSFDAG00000011454	DHX9	99	51.664	Fukomys_damarensis
FBgn0002774	mle	92	51.132	ENSGAGG00000024443	DHX9	95	51.232	Gopherus_agassizii
FBgn0002774	mle	88	54.227	ENSGGOG00000013533	DHX9	93	50.617	Gorilla_gorilla
FBgn0002774	mle	91	44.601	ENSGGOG00000040887	-	95	42.809	Gorilla_gorilla
FBgn0002774	mle	91	53.263	ENSHBUG00000004129	dhx9	94	50.201	Haplochromis_burtoni
FBgn0002774	mle	88	54.469	ENSHGLG00000005769	DHX9	86	51.155	Heterocephalus_glaber_female
FBgn0002774	mle	88	54.469	ENSHGLG00100015628	DHX9	83	51.155	Heterocephalus_glaber_male
FBgn0002774	mle	88	54.722	ENSIPUG00000016675	dhx9	92	51.557	Ictalurus_punctatus
FBgn0002774	mle	92	50.917	ENSSTOG00000016288	DHX9	89	50.863	Ictidomys_tridecemlineatus
FBgn0002774	mle	88	54.162	ENSJJAG00000003249	Dhx9	90	50.120	Jaculus_jaculus
FBgn0002774	mle	64	50.413	ENSLACG00000017767	DHX9	65	50.649	Latimeria_chalumnae
FBgn0002774	mle	88	54.172	ENSLOCG00000002158	dhx9	94	50.936	Lepisosteus_oculatus
FBgn0002774	mle	91	53.638	ENSLAFG00000022058	DHX9	99	49.848	Loxodonta_africana
FBgn0002774	mle	88	54.227	ENSMFAG00000041152	DHX9	99	52.611	Macaca_fascicularis
FBgn0002774	mle	88	54.227	ENSMMUG00000005635	DHX9	93	50.617	Macaca_mulatta
FBgn0002774	mle	88	54.227	ENSMNEG00000041195	DHX9	93	50.617	Macaca_nemestrina
FBgn0002774	mle	88	54.227	ENSMLEG00000039925	DHX9	99	50.985	Mandrillus_leucophaeus
FBgn0002774	mle	88	53.930	ENSMAMG00000018644	dhx9	99	50.327	Mastacembelus_armatus
FBgn0002774	mle	91	53.380	ENSMZEG00005014167	dhx9	94	50.281	Maylandia_zebra
FBgn0002774	mle	91	50.998	ENSMAUG00000020414	Dhx9	86	50.928	Mesocricetus_auratus
FBgn0002774	mle	92	52.254	ENSMICG00000008285	DHX9	95	50.863	Microcebus_murinus
FBgn0002774	mle	91	50.998	ENSMOCG00000019404	Dhx9	93	49.886	Microtus_ochrogaster
FBgn0002774	mle	83	54.710	ENSMMOG00000001268	dhx9	97	49.914	Mola_mola
FBgn0002774	mle	88	53.382	ENSMODG00000006955	DHX9	94	50.617	Monodelphis_domestica
FBgn0002774	mle	85	54.500	ENSMALG00000000318	dhx9	99	50.964	Monopterus_albus
FBgn0002774	mle	91	51.211	MGP_CAROLIEiJ_G0014709	Dhx9	99	52.273	Mus_caroli
FBgn0002774	mle	91	51.336	ENSMUSG00000042699	Dhx9	99	52.470	Mus_musculus
FBgn0002774	mle	91	51.211	MGP_SPRETEiJ_G0015516	Dhx9	94	65.217	Mus_spretus
FBgn0002774	mle	90	53.800	ENSMPUG00000011544	DHX9	98	51.282	Mustela_putorius_furo
FBgn0002774	mle	88	54.469	ENSMLUG00000011163	DHX9	93	51.153	Myotis_lucifugus
FBgn0002774	mle	88	54.106	ENSNLEG00000018013	DHX9	93	50.535	Nomascus_leucogenys
FBgn0002774	mle	61	62.694	ENSMEUG00000001470	-	59	60.096	Notamacropus_eugenii
FBgn0002774	mle	84	57.333	ENSOPRG00000016111	DHX9	92	57.333	Ochotona_princeps
FBgn0002774	mle	88	54.589	ENSODEG00000012659	DHX9	87	50.570	Octodon_degus
FBgn0002774	mle	88	54.414	ENSONIG00000000293	dhx9	93	49.960	Oreochromis_niloticus
FBgn0002774	mle	88	53.083	ENSOANG00000000989	DHX9	93	50.412	Ornithorhynchus_anatinus
FBgn0002774	mle	92	51.039	ENSOCUG00000014651	DHX9	93	51.151	Oryctolagus_cuniculus
FBgn0002774	mle	88	54.414	ENSORLG00000007454	dhx9	99	48.902	Oryzias_latipes
FBgn0002774	mle	91	52.448	ENSORLG00020015369	dhx9	98	49.919	Oryzias_latipes_hni
FBgn0002774	mle	88	54.293	ENSORLG00015000892	dhx9	94	50.000	Oryzias_latipes_hsok
FBgn0002774	mle	88	54.293	ENSOMEG00000002437	dhx9	99	50.082	Oryzias_melastigma
FBgn0002774	mle	88	54.227	ENSOGAG00000002620	DHX9	94	50.567	Otolemur_garnettii
FBgn0002774	mle	88	54.469	ENSOARG00000019089	DHX9	92	51.562	Ovis_aries
FBgn0002774	mle	88	54.227	ENSPPAG00000030190	DHX9	99	52.611	Pan_paniscus
FBgn0002774	mle	92	50.826	ENSPPRG00000005890	DHX9	94	51.149	Panthera_pardus
FBgn0002774	mle	92	50.826	ENSPTIG00000021059	DHX9	94	51.149	Panthera_tigris_altaica
FBgn0002774	mle	88	54.227	ENSPTRG00000001759	DHX9	93	50.617	Pan_troglodytes
FBgn0002774	mle	88	54.227	ENSPANG00000012826	DHX9	93	50.617	Papio_anubis
FBgn0002774	mle	90	54.181	ENSPKIG00000006698	dhx9	93	50.828	Paramormyrops_kingsleyae
FBgn0002774	mle	92	50.876	ENSPSIG00000006241	DHX9	93	50.866	Pelodiscus_sinensis
FBgn0002774	mle	91	52.043	ENSPMGG00000009280	dhx9	93	51.895	Periophthalmus_magnuspinnatus
FBgn0002774	mle	91	50.998	ENSPEMG00000001238	Dhx9	88	50.478	Peromyscus_maniculatus_bairdii
FBgn0002774	mle	88	53.382	ENSPCIG00000003716	DHX9	99	50.453	Phascolarctos_cinereus
FBgn0002774	mle	85	56.000	ENSPFOG00000019152	-	99	52.284	Poecilia_formosa
FBgn0002774	mle	92	53.064	ENSPLAG00000001496	dhx9	97	51.182	Poecilia_latipinna
FBgn0002774	mle	85	55.875	ENSPMEG00000019991	dhx9	98	52.115	Poecilia_mexicana
FBgn0002774	mle	88	54.655	ENSPREG00000019307	dhx9	98	51.221	Poecilia_reticulata
FBgn0002774	mle	88	54.227	ENSPPYG00000000431	DHX9	94	50.617	Pongo_abelii
FBgn0002774	mle	85	46.599	ENSPCAG00000011042	DHX9	87	45.933	Procavia_capensis
FBgn0002774	mle	92	50.624	ENSPCOG00000018029	DHX9	94	50.985	Propithecus_coquereli
FBgn0002774	mle	91	50.501	ENSPVAG00000000836	DHX9	93	50.822	Pteropus_vampyrus
FBgn0002774	mle	88	54.776	ENSPNYG00000008480	dhx9	94	50.774	Pundamilia_nyererei
FBgn0002774	mle	88	55.327	ENSPNAG00000021343	dhx9	94	51.029	Pygocentrus_nattereri
FBgn0002774	mle	92	50.997	ENSRNOG00000002735	Dhx9	99	51.495	Rattus_norvegicus
FBgn0002774	mle	96	51.592	ENSRBIG00000041202	DHX9	93	50.535	Rhinopithecus_bieti
FBgn0002774	mle	96	51.592	ENSRROG00000044740	DHX9	92	52.044	Rhinopithecus_roxellana
FBgn0002774	mle	99	46.478	ENSSBOG00000026174	DHX9	93	47.879	Saimiri_boliviensis_boliviensis
FBgn0002774	mle	94	50.683	ENSSHAG00000008540	DHX9	98	50.453	Sarcophilus_harrisii
FBgn0002774	mle	93	53.440	ENSSFOG00015017378	dhx9	96	50.568	Scleropages_formosus
FBgn0002774	mle	85	54.375	ENSSDUG00000017407	dhx9	99	50.417	Seriola_dumerili
FBgn0002774	mle	89	51.289	ENSSLDG00000003926	dhx9	98	51.064	Seriola_lalandi_dorsalis
FBgn0002774	mle	75	62.810	ENSSARG00000003931	DHX9	91	54.429	Sorex_araneus
FBgn0002774	mle	88	53.382	ENSSPUG00000003934	DHX9	93	50.082	Sphenodon_punctatus
FBgn0002774	mle	88	55.018	ENSSPAG00000009690	dhx9	93	51.552	Stegastes_partitus
FBgn0002774	mle	88	53.744	ENSSSCG00000026806	DHX9	85	50.489	Sus_scrofa
FBgn0002774	mle	67	53.036	ENSTGUG00000004038	-	99	53.265	Taeniopygia_guttata
FBgn0002774	mle	74	57.654	ENSTBEG00000014052	DHX9	70	57.447	Tupaia_belangeri
FBgn0002774	mle	89	50.427	ENSTTRG00000007665	DHX9	99	50.768	Tursiops_truncatus
FBgn0002774	mle	89	51.588	ENSUAMG00000012201	DHX9	99	52.373	Ursus_americanus
FBgn0002774	mle	85	50.134	ENSVPAG00000008097	DHX9	85	50.989	Vicugna_pacos
FBgn0002774	mle	88	54.227	ENSVVUG00000008915	DHX9	93	51.349	Vulpes_vulpes
FBgn0002774	mle	92	50.748	ENSXETG00000012515	dhx9	94	50.945	Xenopus_tropicalis
FBgn0002774	mle	88	54.655	ENSXMAG00000011305	dhx9	95	51.267	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000228	nuclear chromosome	25501352.	IDA	Component
GO:0000785	chromatin	8288132.	IDA	Component
GO:0000805	X chromosome	16079233.18562276.	IDA	Component
GO:0003682	chromatin binding	8288132.	IDA	Function
GO:0003690	double-stranded DNA binding	-	ISS	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	23084835.	IPI	Function
GO:0003724	RNA helicase activity	12717814.	NAS	Function
GO:0003725	double-stranded RNA binding	10908586.	ISS	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	-	ISS	Function
GO:0004386	helicase activity	10908586.	ISS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	18360693.	IDA	Component
GO:0005694	chromosome	8288132.	IDA	Component
GO:0005700	polytene chromosome	1653648.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005829	cytosol	18360693.	IDA	Component
GO:0007549	dosage compensation	25158899.	IDA	Process
GO:0007549	dosage compensation	8288132.	IMP	Process
GO:0007549	dosage compensation	8970731.	TAS	Process
GO:0008026	ATP-dependent helicase activity	8288132.	TAS	Function
GO:0008340	determination of adult lifespan	16272407.	IMP	Process
GO:0009047	dosage compensation by hyperactivation of X chromosome	8970731.10648226.	NAS	Process
GO:0016456	X chromosome located dosage compensation complex, transcription activating	10648226.	NAS	Component
GO:0016456	X chromosome located dosage compensation complex, transcription activating	11178270.	TAS	Component
GO:0016457	dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome	12717814.	TAS	Process
GO:0031453	positive regulation of heterochromatin assembly	18451980.	IGI	Process
GO:0032508	DNA duplex unwinding	-	ISS	Process
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	21873635.	IBA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0045433	male courtship behavior, veined wing generated song production	9504928.	IGI	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	18360693.	IMP	Process
GO:0048675	axon extension	14960616.	IMP	Process
GO:0050684	regulation of mRNA processing	21873635.	IBA	Process
GO:0050684	regulation of mRNA processing	-	ISS	Process
GO:0072487	MSL complex	23084835.	IDA	Component
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	-	ISS	Component
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	-	ISS	Process
GO:2000765	regulation of cytoplasmic translation	-	ISS	Process