EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: MGP_CAROLIEiJ_G0032212 (Gene tree)
Gene ID: 110301379
Gene Symbol: Ddx10
Alias: 4632415A01Rik
Full Name: DEAD-box helicase 10
Gene Type: protein_coding
Species: Mus_caroli
Status: putative
Strand: Minus strand
Length: 142846 bases
Position: chr9:49870522-50013367
Accession: 110301379
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
MGP_CAROLIEiJ_P0087862	ResIII	PF04851.15	4.6e-10	1	1
MGP_CAROLIEiJ_P0087862	DEAD	PF00270.29	2.8e-48	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
MGP_CAROLIEiJ_T0087862	-	3363	XM_021171852	MGP_CAROLIEiJ_P0087862	875 (aa)	XP_021027511	UPI000A316E6C

Gene Model

Click here to download MGP_CAROLIEiJ_G0032212's gene model file

Protein-Protein Interaction (PPI)

Clik here to download MGP_CAROLIEiJ_G0032212's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
MGP_CAROLIEiJ_G0032212	Ddx10	50	46.014	MGP_CAROLIEiJ_G0014529	Ddx18	66	46.014

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.324	ENSG00000178105	DDX10	100	85.324	Homo_sapiens
MGP_CAROLIEiJ_G0032212	Ddx10	84	77.778	ENSAPOG00000009242	ddx10	97	60.114	Acanthochromis_polyacanthus
MGP_CAROLIEiJ_G0032212	Ddx10	100	84.457	ENSAMEG00000009232	DDX10	100	86.254	Ailuropoda_melanoleuca
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.786	ENSACIG00000012927	ddx10	97	60.735	Amphilophus_citrinellus
MGP_CAROLIEiJ_G0032212	Ddx10	84	77.579	ENSAOCG00000021917	ddx10	60	77.668	Amphiprion_ocellaris
MGP_CAROLIEiJ_G0032212	Ddx10	84	77.579	ENSAPEG00000022230	ddx10	63	74.535	Amphiprion_percula
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.482	ENSATEG00000007227	ddx10	97	58.966	Anabas_testudineus
MGP_CAROLIEiJ_G0032212	Ddx10	84	67.862	ENSAPLG00000011942	DDX10	99	68.792	Anas_platyrhynchos
MGP_CAROLIEiJ_G0032212	Ddx10	87	68.627	ENSACAG00000005173	DDX10	99	68.052	Anolis_carolinensis
MGP_CAROLIEiJ_G0032212	Ddx10	100	84.667	ENSANAG00000020864	DDX10	100	84.442	Aotus_nancymaae
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.984	ENSACLG00000003559	ddx10	61	75.483	Astatotilapia_calliptera
MGP_CAROLIEiJ_G0032212	Ddx10	82	72.253	ENSAMXG00000006135	ddx10	98	59.292	Astyanax_mexicanus
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.160	ENSBTAG00000002382	DDX10	100	85.160	Bos_taurus
MGP_CAROLIEiJ_G0032212	Ddx10	52	53.659	WBGene00021277	Y23H5B.6	63	52.916	Caenorhabditis_elegans
MGP_CAROLIEiJ_G0032212	Ddx10	100	84.624	ENSCJAG00000010281	DDX10	100	84.282	Callithrix_jacchus
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.063	ENSCAFG00000014324	DDX10	100	85.291	Canis_familiaris
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.063	ENSCAFG00020007058	DDX10	100	85.291	Canis_lupus_dingo
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.535	ENSCHIG00000015147	DDX10	100	85.421	Capra_hircus
MGP_CAROLIEiJ_G0032212	Ddx10	100	81.663	ENSTSYG00000003184	DDX10	100	81.549	Carlito_syrichta
MGP_CAROLIEiJ_G0032212	Ddx10	100	81.186	ENSCPOG00000000865	DDX10	100	81.870	Cavia_porcellus
MGP_CAROLIEiJ_G0032212	Ddx10	100	84.972	ENSCCAG00000024209	DDX10	100	84.972	Cebus_capucinus
MGP_CAROLIEiJ_G0032212	Ddx10	100	65.525	ENSCATG00000040297	-	100	65.753	Cercocebus_atys
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.530	ENSCATG00000028487	DDX10	100	86.530	Cercocebus_atys
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.317	ENSCLAG00000013463	DDX10	100	86.317	Chinchilla_lanigera
MGP_CAROLIEiJ_G0032212	Ddx10	88	95.475	ENSCSAG00000002948	DDX10	93	95.475	Chlorocebus_sabaeus
MGP_CAROLIEiJ_G0032212	Ddx10	93	85.258	ENSCHOG00000001537	DDX10	93	85.258	Choloepus_hoffmanni
MGP_CAROLIEiJ_G0032212	Ddx10	63	78.097	ENSCPBG00000021681	DDX10	99	66.959	Chrysemys_picta_bellii
MGP_CAROLIEiJ_G0032212	Ddx10	69	59.827	ENSCING00000021618	-	85	56.031	Ciona_intestinalis
MGP_CAROLIEiJ_G0032212	Ddx10	51	61.333	ENSCSAVG00000003023	-	88	56.917	Ciona_savignyi
MGP_CAROLIEiJ_G0032212	Ddx10	87	78.827	ENSCANG00000038108	-	95	78.827	Colobus_angolensis_palliatus
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.893	ENSCANG00000027716	DDX10	100	86.416	Colobus_angolensis_palliatus
MGP_CAROLIEiJ_G0032212	Ddx10	100	91.800	ENSCGRG00001007099	Ddx10	100	92.483	Cricetulus_griseus_chok1gshd
MGP_CAROLIEiJ_G0032212	Ddx10	100	91.800	ENSCGRG00000000153	Ddx10	100	92.483	Cricetulus_griseus_crigri
MGP_CAROLIEiJ_G0032212	Ddx10	75	75.915	ENSCSEG00000002080	ddx10	94	60.625	Cynoglossus_semilaevis
MGP_CAROLIEiJ_G0032212	Ddx10	87	70.778	ENSCVAG00000000109	ddx10	95	70.778	Cyprinodon_variegatus
MGP_CAROLIEiJ_G0032212	Ddx10	58	75.542	ENSDARG00000061865	ddx10	98	58.737	Danio_rerio
MGP_CAROLIEiJ_G0032212	Ddx10	75	83.812	ENSDNOG00000012542	DDX10	99	83.964	Dasypus_novemcinctus
MGP_CAROLIEiJ_G0032212	Ddx10	100	77.195	ENSDORG00000014459	Ddx10	100	77.309	Dipodomys_ordii
MGP_CAROLIEiJ_G0032212	Ddx10	77	54.076	FBgn0030855	CG5800	61	54.076	Drosophila_melanogaster
MGP_CAROLIEiJ_G0032212	Ddx10	93	61.478	ENSETEG00000005526	DDX10	93	61.478	Echinops_telfairi
MGP_CAROLIEiJ_G0032212	Ddx10	58	69.548	ENSEBUG00000007794	ddx10	79	69.548	Eptatretus_burgeri
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.857	ENSEASG00005010110	DDX10	100	87.086	Equus_asinus_asinus
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.629	ENSECAG00000010355	DDX10	100	86.857	Equus_caballus
MGP_CAROLIEiJ_G0032212	Ddx10	100	74.002	ENSEEUG00000011164	DDX10	100	74.230	Erinaceus_europaeus
MGP_CAROLIEiJ_G0032212	Ddx10	58	75.692	ENSELUG00000014515	ddx10	98	59.819	Esox_lucius
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.633	ENSFCAG00000007246	DDX10	100	85.975	Felis_catus
MGP_CAROLIEiJ_G0032212	Ddx10	85	65.314	ENSFALG00000000449	DDX10	98	64.829	Ficedula_albicollis
MGP_CAROLIEiJ_G0032212	Ddx10	99	57.093	ENSFHEG00000011340	ddx10	64	73.837	Fundulus_heteroclitus
MGP_CAROLIEiJ_G0032212	Ddx10	98	58.469	ENSGAFG00000011210	ddx10	89	75.494	Gambusia_affinis
MGP_CAROLIEiJ_G0032212	Ddx10	99	58.381	ENSGACG00000002948	ddx10	98	58.229	Gasterosteus_aculeatus
MGP_CAROLIEiJ_G0032212	Ddx10	99	65.242	ENSGAGG00000023967	DDX10	99	66.289	Gopherus_agassizii
MGP_CAROLIEiJ_G0032212	Ddx10	67	83.752	ENSGGOG00000043387	-	94	86.783	Gorilla_gorilla
MGP_CAROLIEiJ_G0032212	Ddx10	99	73.913	ENSGGOG00000043095	-	100	73.684	Gorilla_gorilla
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.160	ENSGGOG00000000271	-	100	85.160	Gorilla_gorilla
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.786	ENSHBUG00000012476	ddx10	61	75.290	Haplochromis_burtoni
MGP_CAROLIEiJ_G0032212	Ddx10	100	83.618	ENSHGLG00000013439	DDX10	100	83.732	Heterocephalus_glaber_female
MGP_CAROLIEiJ_G0032212	Ddx10	75	89.818	ENSHGLG00100003298	DDX10	94	89.970	Heterocephalus_glaber_male
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.482	ENSHCOG00000010943	ddx10	62	76.482	Hippocampus_comes
MGP_CAROLIEiJ_G0032212	Ddx10	50	45.786	ENSIPUG00000012876	ddx18	75	45.786	Ictalurus_punctatus
MGP_CAROLIEiJ_G0032212	Ddx10	89	69.388	ENSIPUG00000024738	ddx10	98	56.387	Ictalurus_punctatus
MGP_CAROLIEiJ_G0032212	Ddx10	75	89.074	ENSSTOG00000005213	DDX10	97	88.923	Ictidomys_tridecemlineatus
MGP_CAROLIEiJ_G0032212	Ddx10	93	85.153	ENSJJAG00000014261	Ddx10	96	85.521	Jaculus_jaculus
MGP_CAROLIEiJ_G0032212	Ddx10	84	74.851	ENSKMAG00000001578	ddx10	62	74.851	Kryptolebias_marmoratus
MGP_CAROLIEiJ_G0032212	Ddx10	87	74.806	ENSLBEG00000011602	ddx10	94	74.517	Labrus_bergylta
MGP_CAROLIEiJ_G0032212	Ddx10	86	64.276	ENSLOCG00000002074	ddx10	98	64.807	Lepisosteus_oculatus
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.371	ENSLAFG00000005951	DDX10	100	86.515	Loxodonta_africana
MGP_CAROLIEiJ_G0032212	Ddx10	100	63.927	ENSMFAG00000042969	-	100	63.927	Macaca_fascicularis
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.530	ENSMFAG00000045808	DDX10	91	86.530	Macaca_fascicularis
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.301	ENSMMUG00000014415	DDX10	100	86.301	Macaca_mulatta
MGP_CAROLIEiJ_G0032212	Ddx10	100	63.356	ENSMMUG00000016025	-	100	63.356	Macaca_mulatta
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.301	ENSMNEG00000033513	DDX10	100	86.301	Macaca_nemestrina
MGP_CAROLIEiJ_G0032212	Ddx10	100	62.671	ENSMNEG00000039588	-	100	62.671	Macaca_nemestrina
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.519	ENSMLEG00000044081	DDX10	100	86.203	Mandrillus_leucophaeus
MGP_CAROLIEiJ_G0032212	Ddx10	100	63.699	ENSMLEG00000035477	-	100	63.927	Mandrillus_leucophaeus
MGP_CAROLIEiJ_G0032212	Ddx10	98	59.862	ENSMAMG00000022111	ddx10	94	60.759	Mastacembelus_armatus
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.984	ENSMZEG00005003586	ddx10	61	75.483	Maylandia_zebra
MGP_CAROLIEiJ_G0032212	Ddx10	52	84.532	ENSMGAG00000015145	DDX10	99	71.104	Meleagris_gallopavo
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.943	ENSMICG00000035071	DDX10	100	85.943	Microcebus_murinus
MGP_CAROLIEiJ_G0032212	Ddx10	100	92.808	ENSMOCG00000009915	Ddx10	100	92.694	Microtus_ochrogaster
MGP_CAROLIEiJ_G0032212	Ddx10	99	75.316	ENSMODG00000014600	DDX10	96	75.431	Monodelphis_domestica
MGP_CAROLIEiJ_G0032212	Ddx10	82	78.351	ENSMALG00000021441	ddx10	89	78.512	Monopterus_albus
MGP_CAROLIEiJ_G0032212	Ddx10	100	96.914	ENSMUSG00000053289	Ddx10	100	96.914	Mus_musculus
MGP_CAROLIEiJ_G0032212	Ddx10	100	96.571	MGP_PahariEiJ_G0015080	Ddx10	100	96.571	Mus_pahari
MGP_CAROLIEiJ_G0032212	Ddx10	100	98.286	MGP_SPRETEiJ_G0033352	Ddx10	100	98.286	Mus_spretus
MGP_CAROLIEiJ_G0032212	Ddx10	100	86.057	ENSMPUG00000005921	DDX10	100	86.057	Mustela_putorius_furo
MGP_CAROLIEiJ_G0032212	Ddx10	75	84.545	ENSMLUG00000001645	DDX10	98	84.242	Myotis_lucifugus
MGP_CAROLIEiJ_G0032212	Ddx10	100	89.384	ENSNGAG00000010526	Ddx10	100	89.384	Nannospalax_galili
MGP_CAROLIEiJ_G0032212	Ddx10	58	77.075	ENSNBRG00000016684	ddx10	60	77.075	Neolamprologus_brichardi
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.324	ENSNLEG00000007242	DDX10	100	85.731	Nomascus_leucogenys
MGP_CAROLIEiJ_G0032212	Ddx10	93	66.340	ENSOPRG00000004266	DDX10	100	65.728	Ochotona_princeps
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.877	ENSONIG00000007263	ddx10	91	59.771	Oreochromis_niloticus
MGP_CAROLIEiJ_G0032212	Ddx10	73	76.698	ENSOANG00000006243	DDX10	99	75.228	Ornithorhynchus_anatinus
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.486	ENSOCUG00000003843	DDX10	100	85.486	Oryctolagus_cuniculus
MGP_CAROLIEiJ_G0032212	Ddx10	99	57.016	ENSORLG00000003073	ddx10	99	57.572	Oryzias_latipes
MGP_CAROLIEiJ_G0032212	Ddx10	56	76.955	ENSORLG00015002672	ddx10	99	58.050	Oryzias_latipes_hsok
MGP_CAROLIEiJ_G0032212	Ddx10	59	73.106	ENSOMEG00000007443	ddx10	64	72.932	Oryzias_melastigma
MGP_CAROLIEiJ_G0032212	Ddx10	75	85.562	ENSOGAG00000010962	DDX10	98	85.562	Otolemur_garnettii
MGP_CAROLIEiJ_G0032212	Ddx10	75	86.295	ENSOARG00000012714	DDX10	99	86.145	Ovis_aries
MGP_CAROLIEiJ_G0032212	Ddx10	100	84.139	ENSPPAG00000035222	DDX10	100	85.227	Pan_paniscus
MGP_CAROLIEiJ_G0032212	Ddx10	99	73.570	ENSPPAG00000032506	-	100	73.799	Pan_paniscus
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.633	ENSPPRG00000005990	DDX10	100	85.975	Panthera_pardus
MGP_CAROLIEiJ_G0032212	Ddx10	93	86.012	ENSPTIG00000010152	DDX10	93	86.380	Panthera_tigris_altaica
MGP_CAROLIEiJ_G0032212	Ddx10	99	74.027	ENSPTRG00000047351	-	100	73.455	Pan_troglodytes
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.324	ENSPTRG00000004256	DDX10	100	85.324	Pan_troglodytes
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.747	ENSPANG00000015325	DDX10	100	86.431	Papio_anubis
MGP_CAROLIEiJ_G0032212	Ddx10	100	69.635	ENSPANG00000029813	-	100	69.863	Papio_anubis
MGP_CAROLIEiJ_G0032212	Ddx10	99	56.527	ENSPKIG00000015739	ddx10	99	56.883	Paramormyrops_kingsleyae
MGP_CAROLIEiJ_G0032212	Ddx10	90	67.677	ENSPSIG00000014874	DDX10	99	73.782	Pelodiscus_sinensis
MGP_CAROLIEiJ_G0032212	Ddx10	57	77.291	ENSPMGG00000008344	ddx10	62	77.291	Periophthalmus_magnuspinnatus
MGP_CAROLIEiJ_G0032212	Ddx10	100	84.642	ENSPEMG00000017492	Ddx10	100	84.091	Peromyscus_maniculatus_bairdii
MGP_CAROLIEiJ_G0032212	Ddx10	98	76.064	ENSPCIG00000003013	DDX10	99	89.871	Phascolarctos_cinereus
MGP_CAROLIEiJ_G0032212	Ddx10	98	57.639	ENSPFOG00000013021	ddx10	89	74.901	Poecilia_formosa
MGP_CAROLIEiJ_G0032212	Ddx10	98	58.053	ENSPLAG00000009048	ddx10	89	74.901	Poecilia_latipinna
MGP_CAROLIEiJ_G0032212	Ddx10	98	57.755	ENSPMEG00000004541	ddx10	95	69.094	Poecilia_mexicana
MGP_CAROLIEiJ_G0032212	Ddx10	98	58.605	ENSPREG00000019559	ddx10	95	69.805	Poecilia_reticulata
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.666	ENSPPYG00000003849	DDX10	100	86.073	Pongo_abelii
MGP_CAROLIEiJ_G0032212	Ddx10	100	70.159	ENSPCAG00000012949	DDX10	100	70.159	Procavia_capensis
MGP_CAROLIEiJ_G0032212	Ddx10	92	84.247	ENSPCOG00000020289	DDX10	100	84.247	Propithecus_coquereli
MGP_CAROLIEiJ_G0032212	Ddx10	100	80.091	ENSPVAG00000007371	DDX10	100	81.001	Pteropus_vampyrus
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.984	ENSPNYG00000001756	ddx10	97	59.195	Pundamilia_nyererei
MGP_CAROLIEiJ_G0032212	Ddx10	58	74.753	ENSPNAG00000017154	ddx10	98	60.478	Pygocentrus_nattereri
MGP_CAROLIEiJ_G0032212	Ddx10	100	94.857	ENSRNOG00000012500	Ddx10	100	94.857	Rattus_norvegicus
MGP_CAROLIEiJ_G0032212	Ddx10	100	63.098	ENSRBIG00000038689	-	98	62.984	Rhinopithecus_bieti
MGP_CAROLIEiJ_G0032212	Ddx10	100	82.159	ENSRBIG00000040612	DDX10	100	82.896	Rhinopithecus_bieti
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.682	ENSRROG00000031744	DDX10	100	86.431	Rhinopithecus_roxellana
MGP_CAROLIEiJ_G0032212	Ddx10	51	54.343	YJL033W	HCA4	58	54.343	Saccharomyces_cerevisiae
MGP_CAROLIEiJ_G0032212	Ddx10	100	82.353	ENSSBOG00000022735	DDX10	100	82.353	Saimiri_boliviensis_boliviensis
MGP_CAROLIEiJ_G0032212	Ddx10	99	60.541	ENSSFOG00015007982	ddx10	98	60.134	Scleropages_formosus
MGP_CAROLIEiJ_G0032212	Ddx10	59	74.181	ENSSMAG00000018735	ddx10	62	74.181	Scophthalmus_maximus
MGP_CAROLIEiJ_G0032212	Ddx10	59	74.664	ENSSDUG00000018245	ddx10	62	74.664	Seriola_dumerili
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.285	ENSSLDG00000012041	ddx10	62	74.856	Seriola_lalandi_dorsalis
MGP_CAROLIEiJ_G0032212	Ddx10	78	94.231	ENSSARG00000004103	DDX10	78	94.231	Sorex_araneus
MGP_CAROLIEiJ_G0032212	Ddx10	85	66.579	ENSSPUG00000017612	DDX10	89	67.282	Sphenodon_punctatus
MGP_CAROLIEiJ_G0032212	Ddx10	58	76.969	ENSSPAG00000015548	ddx10	91	71.631	Stegastes_partitus
MGP_CAROLIEiJ_G0032212	Ddx10	93	66.346	ENSTGUG00000012605	DDX10	100	65.862	Taeniopygia_guttata
MGP_CAROLIEiJ_G0032212	Ddx10	96	59.251	ENSTRUG00000010881	ddx10	60	75.649	Takifugu_rubripes
MGP_CAROLIEiJ_G0032212	Ddx10	96	59.905	ENSTNIG00000010477	ddx10	98	58.633	Tetraodon_nigroviridis
MGP_CAROLIEiJ_G0032212	Ddx10	85	76.730	ENSTBEG00000006321	DDX10	91	76.730	Tupaia_belangeri
MGP_CAROLIEiJ_G0032212	Ddx10	100	76.310	ENSTTRG00000006068	DDX10	100	76.424	Tursiops_truncatus
MGP_CAROLIEiJ_G0032212	Ddx10	57	96.008	ENSUAMG00000014176	DDX10	100	96.008	Ursus_americanus
MGP_CAROLIEiJ_G0032212	Ddx10	93	86.397	ENSUMAG00000007300	DDX10	98	86.397	Ursus_maritimus
MGP_CAROLIEiJ_G0032212	Ddx10	92	85.093	ENSVPAG00000010185	DDX10	100	85.093	Vicugna_pacos
MGP_CAROLIEiJ_G0032212	Ddx10	100	85.405	ENSVVUG00000015484	DDX10	100	85.519	Vulpes_vulpes
MGP_CAROLIEiJ_G0032212	Ddx10	69	69.243	ENSXETG00000014458	ddx10	85	69.901	Xenopus_tropicalis
MGP_CAROLIEiJ_G0032212	Ddx10	99	57.798	ENSXCOG00000003080	ddx10	98	68.467	Xiphophorus_couchianus
MGP_CAROLIEiJ_G0032212	Ddx10	98	58.304	ENSXMAG00000016515	ddx10	95	69.272	Xiphophorus_maculatus