E3 ubiquitin ligase%3B forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123%2C which is required for the subsequent methylation of histone H3-K4 and H3-K79%3B required for DSBR%2C transcription%2C silencing%2C and checkpoint control%3B interacts with RNA-binding protein Npl3p%2C linking histone ubiquitination to mRNA processing%3B Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing
