Component of a Cdc48p-complex involved in protein quality control%3B exhibits cytosolic and ER-membrane localization%2C with Cdc48p%2C during normal growth%2C and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination%3B forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD)%3B conserved in C. elegans and humans
