Ubiquitin-protein ligase subunit of the CCR4-NOT complex%3B with Ubc4p%2C ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p%3B CCR4-NOT has roles in transcription regulation%2C mRNA degradation%2C and post-transcriptional modifications%3B regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication