Integral ER membrane protein%2C regulates phospholipid metabolism%3B one of 6 proteins (Ist2p%2C Scs2p%2C Scs22p%2C Tcb1p%2C Tcb2p%2C Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM%3B interacts with FFAT motifs in Opi1p%2C Swh1p%2C Osh2p%2C and Osh3p%3B involved in telomeric silencing%3B VAP homolog%3B SCS2 has a paralog%2C SCS22%2C that arose from the whole genome duplication
