Highly conserved subunit of mitochondrial pyruvate carrier (MPC)%3B MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth%2C or Mcp1p and Mpc3p during respiratory growth%3B null mutant displays slow growth that is complemented by expression of human or mouse ortholog%3B mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia
