Member of the NineTeen Complex (NTC)%3B NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2%2C U5%2C and U6 snRNAs%3B relocalizes to the cytosol in response to hypoxia%3B isy1 syf2 cells have defective spindles activiating cell cycle arrest