Protein kinase involved in the cell cycle checkpoint into anaphase%3B in complex with Mad1p and Bub3p%2C prevents progression into anaphase in presence of spindle damage%3B Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest%3B associates with centromere DNA via Skp1p%3B involved in Sgo1p relocalization in response to sister kinetochore tension%3B paralog MAD3 arose from whole genome duplication
