Nucleoside triphosphate pyrophosphohydrolase%3B active against various substrates including ITP%2C dITP and XTP%3B mediates exclusion of non canonical purines%2C pyrimidines from dNTP pools%3B functions with YJL055W to mediate resistance to 5-FU%3B specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA%3B protein abundance increases in response to DNA replication stress%3B yeast HAM1 can complement knockdown of human homolog ITPA
