FG-nucleoporin component of central core of nuclear pore complex (NPC)%3B also part of the NPC nuclear basket%3B contributes directly to nucleocytoplasmic transport%3B involved in regulation of transcription and mitosis%3B induces membrane tubulation%2C which may contribute to nuclear pore assembly%3B NUP53 has a paralog%2C ASM4%2C that arose from the whole genome duplication