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Members of this family are coiled-coil proteins that are involved in pre-rRNA processing .
Cgr1 is involved in nucleolar integrity and is required for processing pre-rRNA for the 60S ribosome subunit. In Saccharomyces cerevisiae, this protein is conserved and contributes to compartmentalisation of nucleolar constituents [PUBMED:11932453]. Cgr1 is a small hydrophilic protein and members of this family are coiled-coil proteins [PUBMED:11932453]. Its primary role appears to be in ribosome biogenesis [PUBMED:11116400, PUBMED:11342110]. Expression of CGR1 is also associated with a cessation of yeast cell growth, which is a prerequisite for germination in this organism [PUBMED:11342110].
Moy TI, Boettner D, Rhodes JC, Silver PA, Askew DS; , Microbiology 2002;148:1081-1090.: Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. PUBMED:11932453 EPMC:11932453.