Microtus_ochrogasterFamily: Exo_endo_phos Number of Genes: 24
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Tdp2
Apex2
Smpd5
Inpp5e
Inpp5k
Dnase1l3
Inppl1
Cnot6l
Ocrl
Noct
-
Apex1
Inpp5a
Inpp5j
Dnase1l1
-
Inpp5b
Dnase1
Smpd2
Synj2
Pde12
Inpp5d
-
Dnase1l2
Cnot6
Angel2
Angel1

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

  1. Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .

  2. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .

  3. Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.