EuRBPDB

Microtus_ochrogasterFamily: Exo_endo_phos Number of Genes: 24

Ensembl ID	Symbol	Entrez ID
ENSMOCG00000002823	Tdp2	101984753
ENSMOCG00000004339	Apex2	101990828
ENSMOCG00000004813	Smpd5	101998229
ENSMOCG00000005052	Inpp5e	102001235
ENSMOCG00000005686	Inpp5k	101989449
ENSMOCG00000006651	Dnase1l3	101994836
ENSMOCG00000008314	Inppl1	101991608
ENSMOCG00000009451	Cnot6l	101987435
ENSMOCG00000010531	Ocrl	102001097
ENSMOCG00000013676	Noct	-
ENSMOCG00000013721	Apex1	101991820
ENSMOCG00000016229	Inpp5a	101979661
ENSMOCG00000016640	Inpp5j	101996458
ENSMOCG00000017402	Dnase1l1	-
ENSMOCG00000017902	Inpp5b	102002752
ENSMOCG00000018529	Dnase1	101980782
ENSMOCG00000019666	Smpd2	101981116
ENSMOCG00000020054	Synj2	102000928
ENSMOCG00000020734	Pde12	102000489
ENSMOCG00000020774	Inpp5d	-
ENSMOCG00000020957	Dnase1l2	101989542
ENSMOCG00000021662	Cnot6	101983691
ENSMOCG00000022027	Angel2	102002164
ENSMOCG00000022911	Angel1	101983643

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.