EuRBPDB

Mus_musculus_c3hhejFamily: Exo_endo_phos Number of Genes: 24

Ensembl ID	Symbol	Entrez ID
MGP_C3HHeJ_G0016034	Inpp5d	-
MGP_C3HHeJ_G0016694	Angel2	-
MGP_C3HHeJ_G0016934	Smpd2	-
MGP_C3HHeJ_G0017713	-	-
MGP_C3HHeJ_G0017987	Cnot6	-
MGP_C3HHeJ_G0018472	Inpp5k	-
MGP_C3HHeJ_G0019715	Angel1	-
MGP_C3HHeJ_G0020133	Tdp2	-
MGP_C3HHeJ_G0020720	Dnase1l3	-
MGP_C3HHeJ_G0020820	Pde12	-
MGP_C3HHeJ_G0021002	Apex1	-
MGP_C3HHeJ_G0022193	Dnase1	-
MGP_C3HHeJ_G0022763	Synj1	-
MGP_C3HHeJ_G0022841	Synj2	-
MGP_C3HHeJ_G0023024	Dnase1l2	-
MGP_C3HHeJ_G0025222	Inpp5e	-
MGP_C3HHeJ_G0026908	Noct	-
MGP_C3HHeJ_G0028449	Inpp5b	-
MGP_C3HHeJ_G0029462	Cnot6l	-
MGP_C3HHeJ_G0032289	Inppl1	-
MGP_C3HHeJ_G0032847	Inpp5a	-
MGP_C3HHeJ_G0035358	Ocrl	-
MGP_C3HHeJ_G0035508	Dnase1l1	-
MGP_C3HHeJ_G0035843	Apex2	-

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.