This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling . This family includes: AP endonuclease proteins EC:220.127.116.11 e.g P27695 DNase I proteins EC:18.104.22.168 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:22.214.171.124 O43426 Sphingomyelinase EC:126.96.36.199 P11889 and Nocturnin O35710.
This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).