Microtus_ochrogasterFamily: FDF Number of Genes: 4
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
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Lsm14a
Edc3
Lsm14b

Introduction

Pfam

The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops [1]. It is found at the C terminus of Scd6p-like SM domains [1]. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain [1].

InterPro

The FDF domain, so called because of the conserved FDF at its N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops [PUBMED:15257761]. It is found at the C terminus of Scd6p-like SM domains [PUBMED:15257761, PUBMED:15225602]. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N-terminal to the YjeF-N domain, a novel Rossmann fold domain [PUBMED:15257761].

Reference

  1. Anantharaman V, Aravind L;, BMC Genomics. 2004;5:45.: Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. PUBMED:15257761 EPMC:15257761 .

  2. Albrecht M, Lengauer T; , FEBS Lett 2004;569:18-26.: Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. PUBMED:15225602 EPMC:15225602 .

  3. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E, Weichenrieder O;, Mol Cell. 2009;33:661-668.: Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. PUBMED:19285948 EPMC:19285948.