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eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3 [1,2]. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA .
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Garcia-Barrio MT, Naranda T, Vazquez de Aldana CR, Cuesta R, Hinnebusch AG, Hershey JW, Tamame M; , Genes Dev 1995;9:1781-1796.: GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3. PUBMED:7542616 EPMC:7542616 .
Anderson J, Phan L, Cuesta R, Carlson BA, Pak M, Asano K, Bjork GR, Tamame M, Hinnebusch AG; , Genes Dev 1998;12:3650-3662.: The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. PUBMED:9851972 EPMC:9851972 .
Anderson J, Phan L, Hinnebusch AG; , Proc Natl Acad Sci U S A 2000;97:5173-5178.: The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. PUBMED:10779558 EPMC:10779558.