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The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains .
The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed alpha-hairpin subdomains, and is involved in interactions with DNA and protein.
Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, Hickson ID; , EMBO J. 2005;24:2679-2687.: The HRDC domain of BLM is required for the dissolution of double Holliday junctions. PUBMED:15990871 EPMC:15990871 .
Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M, Bork P, Sattler M; , Structure. 1999;7:1557-1566.: The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. PUBMED:10647186 EPMC:10647186 .
Huang L, Hua X, Lu H, Gao G, Tian B, Shen B, Hua Y; , DNA Repair (Amst). 2006; [Epub ahead of print]: Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans. PUBMED:17085080 EPMC:17085080.