|Ensembl ID||Symbol||Entrez ID||RBD||RBPome||PRI||Expresion||Pathway||Phenotype||Paralog||Ortholog||GO|
Members of this family adopt a structure consisting of a small globular all-beta-domain, with a three-stranded beta-sheet and a contiguous beta-hairpin. They bind to Mago alpha-helices via extensive electrostatic interactions and at a beta2-beta3 loop via hydrophobic interactions .
Partner of Y14 and mago (PYM, also known as WIBG) is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation [PUBMED:18026120, PUBMED:19410547].
Bono F, Ebert J, Unterholzner L, Guttler T, Izaurralde E, Conti E; , EMBO Rep. 2004;5:304-310.: Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. PUBMED:14968132 EPMC:14968132.