Rattus_norvegicusFamily: NTF2 Number of Genes: 11
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
G3bp2
Nxt1
Nxf2
G3bp1
Nutf2
Nxf1
Nxt2
Nxf7
Nxf3
AABR07061614.1
-
AABR07040617.1
-

Introduction

Pfam

This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.

InterPro

Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity [PUBMED:9533885].

Reference

  1. Stewart M, Kent HM, McCoy AJ; , J Mol Biol 1998;277:635-646.: Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. PUBMED:9533885 EPMC:9533885.