Homo_sapiensFamily: Nop53 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation [3]. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60) [1]. This protein has been found to interact with herpes simplex type 1 regulatory proteins [1].


No InterPro abstract


  1. Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB; , Genomics 2000;64:44-50.: A transcript map of the chromosome 19q-arm glioma tumor suppressor region. PUBMED:10708517 EPMC:10708517 .

  2. Bruni R, Fineschi B, Ogle WO, Roizman B; , J Virol 1999;73:3810-3817.: A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection. PUBMED:10196275 EPMC:10196275 .

  3. Sydorskyy Y, Dilworth DJ, Halloran BP, Yi EC, Makhnevych TR, Wozniak RW, Aitchison JD; , Biochem J 2005; [Epub ahead of print]: Nop53p is a novel nucleolar 60S ribosomal biogenesis protein. PUBMED:15686447 EPMC:15686447.