EuRBPDB

Microtus_ochrogasterFamily: PRO8NT Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Prpf8

Introduction

Pfam

The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [4].

InterPro

The PRO8NT domain is found at the N terminus of pre-mRNA splicing factors of PRO8 family [PUBMED:15112237]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [PUBMED:16431982].

Reference

  1. Staub E, Fiziev P, Rosenthal A, Hinzmann B; , Bioessays 2004;26:567-581.: Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. PUBMED:15112237 EPMC:15112237 .

  2. Grainger RJ, Beggs JD; , RNA. 2005;11:533-557.: Prp8 protein: at the heart of the spliceosome. PUBMED:15840809 EPMC:15840809 .

  3. Boon KL, Norman CM, Grainger RJ, Newman AJ, Beggs JD; , RNA. 2006;12:198-205.: Prp8p dissection reveals domain structure and protein interaction sites. PUBMED:16373487 EPMC:16373487 .

  4. Turner IA, Norman CM, Churcher MJ, Newman AJ; , RNA. 2006;12:375-386.: Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome. PUBMED:16431982 EPMC:16431982.