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This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with PF01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.
This domain is found in eukaryotes, and is typically between 212 and 238 amino acids in length. It is found in association with . There are two completely conserved residues (W and H) that may be functionally important. It is found in the subunit 1 of mammalian splicing factor SF3A, which is involved in converting the U2 snRNP into its active form during pre-mRNA splicing [PUBMED:7489498].
Arenas JE, Abelson JN;, Proc Natl Acad Sci U S A. 1993;90:6771-6775.: The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome. PUBMED:8341697 EPMC:8341697 .
Kramer A, Mulhauser F, Wersig C, Groning K, Bilbe G;, RNA. 1995;1:260-272.: Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae. PUBMED:7489498 EPMC:7489498.