Saccharomyces_cerevisiaeFamily: Pept_tRNA_hydro Number of Genes: 1
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No Pfam abstract.


Peptidyl-tRNA hydrolase (EC) (PTH) is a bacterial enzyme that cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. The natural substrate for this enzyme may be peptidyl-tRNA which drop off the ribosome during protein synthesis [PUBMED:1833189, PUBMED:8635758]. Bacterial PTH has been found to be evolutionary related to a yeast protein [PUBMED:8563640].


  1. Schmitt E, Mechulam Y, Fromant M, Plateau P, Blanquet S; , EMBO J 1997;16:4760-4769.: Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase. PUBMED:9303320 EPMC:9303320.