| Ensembl ID | Symbol | Entrez ID | RBD | RBPome | PRI | Expresion | Pathway | Phenotype | Paralog | Ortholog | GO |
|---|---|---|---|---|---|---|---|---|---|---|---|
Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity [1]. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.i
This entry represents the N-terminal domain of the T4 RNA ligase 1 (also known as Rnl1). Host defence to phage may include cleavage and inactivation of specific tRNA molecules; Rnl1 acts to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. Proteins containing this domain also include fungal tRNA ligases that have adenylyltransferase activity [PUBMED:12933796]. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. Please see the following relevant references: [PUBMED:12466548, PUBMED:1922054].
Sawaya R, Schwer B, Shuman S; , J Biol Chem 2003;278:43928-43938.: Genetic and biochemical analysis of the functional domains of yeast tRNA ligase. PUBMED:12933796 EPMC:12933796.
