|Ensembl ID||Symbol||Entrez ID||RBD||RBPome||PRI||Expresion||Pathway||Phenotype||Paralog||Ortholog||GO|
This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II termination factor for noncoding RNA genes . The N terminal of SEN1, unlike the C terminal, is not required for growth .
The yeast helicase Sen1 is an ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs [PUBMED:8943355, PUBMED:15121901]. The C-terminal domain of Sen1 is essential for cell growth, while the N-terminal domain appears to be dispensible [PUBMED:1569945]. This entry represents the N-terminal domain.
DeMarini DJ, Winey M, Ursic D, Webb F, Culbertson MR;, Mol Cell Biol. 1992;12:2154-2164.: SEN1, a positive effector of tRNA-splicing endonuclease in Saccharomyces cerevisiae. PUBMED:1569945 EPMC:1569945 .
Steinmetz EJ, Warren CL, Kuehner JN, Panbehi B, Ansari AZ, Brow DA;, Mol Cell. 2006;24:735-746.: Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase. PUBMED:17157256 EPMC:17157256.