EuRBPDB

Mus_caroliFamily: Smg4_UPF3 Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
MGP_CAROLIEiJ_G0030848	Upf3a	110300617
MGP_CAROLIEiJ_G0032999	Upf3b	110286750

Introduction

Pfam

This family contains proteins that are involved in nonsense mediated mRNA decay. A process that is triggered by premature stop codons in mRNA. The family includes Smg-4 [1] and UPF3.

InterPro

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism by which eukaryotic cells detect and degrade transcripts containing premature termination codons. Three 'up-frameshift' proteins, UPF1, UPF2 and UPF3, are essential for this process in organisms ranging from yeast, human to plants [PUBMED:11368911]. Exon junction complexes (EJCs) are deposited ~24 nucleotides upstream of exon-exon junctions after splicing. Translation causes displacement of the EJCs, however, premature translation termination upstream of one or more EJCs triggers the recruitment of UPF1, UPF2 and UPF3 and activates the NMD pathway [PUBMED:12718880, PUBMED:15048104].

Reference

Aronoff R, Baran R, Hodgkin J; , Gene 2001;268:153-164.: Molecular identification of smg-4, required for mRNA surveillance in C. elegans. PUBMED:11368911 EPMC:11368911.