This family of proteins is snRNA-activating protein complex subunit 2 (SnAPC subunit 2). SnAPC complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box . The family functions both to specifically recognise the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighbouring TATA box present in human U6 snRNA promoters [2,3].
This family of proteins is SnAPC subunit 2-like. SnAPC allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element [PUBMED:16603380].
Sadowski CL, Henry RW, Kobayashi R, Hernandez N;, Proc Natl Acad Sci U S A. 1996;93:4289-4293.: The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein. PUBMED:8633057 EPMC:8633057 .
Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW;, J Biol Chem. 2003;278:18649-18657.: The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. PUBMED:12621023 EPMC:12621023 .
Hanzlowsky A, Jelencic B, Jawdekar G, Hinkley CS, Geiger JH, Henry RW; , Protein Expr Purif. 2006;48:215-223.: Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III. PUBMED:16603380 EPMC:16603380.