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This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4 . TRM13 shows no sequence similarity to other known methyltransferases.
This entry consists of eukaryotic and bacterial proteins that specifically methylates guanosine-4 in various tRNAs with a Gly(CCG), His or Pro signatures [PUBMED:17242307]. The alignment contains some conserved cysteines and histidines that might form a zinc binding site.
Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM; , RNA. 2007; [Epub ahead of print]: The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. PUBMED:17242307 EPMC:17242307.