EuRBPDB

Drosophila_melanogasterFamily: Tudor-knot Number of Genes: 4

Ensembl ID	Symbol	Entrez ID
FBgn0014340	mof	31518
FBgn0026080	Tip60	31362
FBgn0027378	MRG15	41850
FBgn0085451	htk	32877

Introduction

Pfam

This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding [1].

InterPro

This is a novel knotted tudor domain which is required for binding to RNA. The knot influences the loop conformation of the helical turn Ht2 (residues 61-63) that is located at the side opposite the knot in the tudor domain-chromo domain; stabilisation of Ht2 is essential for RNA binding [PUBMED:18407291].

Reference

Shimojo H, Sano N, Moriwaki Y, Okuda M, Horikoshi M, Nishimura Y; , J Mol Biol. 2008;378:987-1001.: Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain. PUBMED:18407291 EPMC:18407291.