EuRBPDB

Gambusia_affinisFamily: UPF1_Zn_bind Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
upf1
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Introduction

Pfam

UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [1].

InterPro

UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [PUBMED:16931876].

Reference

  1. Kadlec J, Guilligay D, Ravelli RB, Cusack S; , RNA. 2006;12:1817-1824.: Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1. PUBMED:16931876 EPMC:16931876.