EuRBPDB

Mus_caroliFamily: UPF1_Zn_bind Number of Genes: 1

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
MGP_CAROLIEiJ_G0031142	Upf1	110299629

Introduction

Pfam

UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [1].

InterPro

UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [PUBMED:16931876].

Reference

Kadlec J, Guilligay D, Ravelli RB, Cusack S; , RNA. 2006;12:1817-1824.: Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1. PUBMED:16931876 EPMC:16931876.