EuRBPDB

Microtus_ochrogasterFamily: Upf2 Number of Genes: 1

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSMOCG00000008263	Upf2	101998508

Introduction

Pfam

Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay [1].

InterPro

This entry represents Up-frameshift suppressor 2 (also known as Nonsense-mediated mRNA decay protein 2). Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay [PUBMED:11073994].

Reference

Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC; , Mol Cell Biol 2000;20:8944-8957.: Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. PUBMED:11073994 EPMC:11073994.