Xiphophorus_couchianusFamily: Upf2 Number of Genes: 1
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
UPF2
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Introduction

Pfam

Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay [1].

InterPro

This entry represents Up-frameshift suppressor 2 (also known as Nonsense-mediated mRNA decay protein 2). Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay [PUBMED:11073994].

Reference

  1. Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC; , Mol Cell Biol 2000;20:8944-8957.: Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. PUBMED:11073994 EPMC:11073994.