Saccharomyces_cerevisiaeFamily: Utp12 Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2 Q12220 [1].


A large ribonuclear protein complex is required for the processing of the small-ribosomal-subunit rRNA - the small-subunit (SSU) processome [PUBMED:12068309, PUBMED:15590835]. This preribosomal complex contains the U3 snoRNA and at least 40 proteins, which have the following properties:


  1. Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ; , Nature 2002;0:0-0.: A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. PUBMED:12068309 EPMC:12068309.