This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with PF02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This complex binds various eIF_4E-BPs (binding proteins) to regulate initiation of translation.
The eukaryotic initiation factor 4G (eIF4G) is the core of a multicomponent switch controlling gene expression at the level of translation initiation. It interacts with the small ribosomal subunit interacting protein, eIF3, and the eIF4E/cap-mRNA complex in order to load the ribosome onto mRNA during cap-dependent translation.
Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G;, Cell. 2003;115:739-750.: Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. PUBMED:14675538 EPMC:14675538.
