Pan_paniscusFamily: zf-C2H2 Number of Genes: 92
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ZBTB37
MYNN
ZBTB26
ZNF574
ZBTB24
ZSCAN5B
BNC1
-
-
-
SNAI2
ZSCAN4
ZNF319
ZBTB14
ZNF800
ZNF652
ZBTB34
ZEB2
ZBTB6
-
ZNF426
ZSCAN5C
ZNF687
ZBTB49
ZNF784
GZF1
ZBTB47
ZFP64
ZNF224
BCL6
ZBTB41
ZFHX4
ZNF582
-
-
-
ZNF205
ZIC3
ZNF233
ZFAT
ZBTB32
ZNF235
-
-
OVOL2
-
ZNF628
-
ZFP1
PATZ1
BCL6B
ZNF860
-
ZNF600
-
ZBTB12
-
-
ZBTB20
ZNF267
ZNF317
ZBTB40
ZNF701
-
-
ZBTB16
ZNF408
ZNF888
ZNF829
ZBTB44
ZSCAN5A
ZEB1
SALL1
ZNF367
RREB1
BNC2
-
HIC2
ZNF225
SALL4
ZNF808
ZNF226
SALL2
-
ZNF236
PRDM4
ZNF683
ZNF423
ZNF354A
ZNF768
ZNF112
SNAI1
-
-
-
-
-
-
GFI1
ZNF2
HINFP
PRDM10
PRDM5
SNAI3
ZNF384

Introduction

Pfam

The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [2].

InterPro

No InterPro abstract

Reference

  1. Boehm S, Frishman D, Mewes HW; , Nucleic Acids Res 1997;25:2464-2469.: Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. PUBMED:9171100 EPMC:9171100 .

  2. Marco E, Garcia-Nieto R, Gago F; , J Mol Biol 2003;328:9-32.: Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. PUBMED:12683994 EPMC:12683994.