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This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation . The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila .
This family consists of family member 1 (proto-oncogene AF4), family member 2 or FMR2 (Fragile X E mental retardation syndrome), family member 3 or LAF4 (lymphoid nuclear protein related to AF4) and family member 4 (protein lilliputian). Lilliputian is a Drosophila AF4 protein homologue which contains an AT-hook domain. It represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [PUBMED:11171404].
Wittwer F, van der Straten A, Keleman K, Dickson BJ, Hafen E; , Development 2001;128:791-800.: Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. PUBMED:11171403 EPMC:11171403 .
Tang AH, Neufeld TP, Rubin GM, Muller HA; , Development 2001;128:801-813.: Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian. PUBMED:11171404 EPMC:11171404.