Homo_sapiensFamily: Brix Number of Genes: 5
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO



No Pfam abstract.


Analysis of the Brix (biogenesis of ribosomes in Xenopus) protein leaded to the identification of a region of 150-180 residues length, called the Brix domain, which is found in six protein families: one archaean family (I) including hypothetical proteins (one per genome); and five eukaryote families, each named according to a representative member and including close homologues of this prototype: (II) Peter Pan (D. melanogaster) and SSF1/2 (S.cerevisiae); (III) RPF1 (S. cerevisiae); (IV) IMP4 (S. cerevisiae); (V) Brix (X.laevis) and BRX1 (S. cerevisiae); and (VI) RPF2 (S.cerevisiae).


  1. Eisenhaber F, Wechselberger C, Kreil G; , Trends Biochem Sci 2001;26:345-347.: The Brix domain protein family -- a key to the ribosomal biogenesis pathway? PUBMED:11406393 EPMC:11406393 .

  2. Mayer C, Suck D, Poch O; , Trends Biochem Sci 2001;26:143-144.: The archaeal homolog of the Imp4 protein, a eukaryotic U3 snoRNP component. PUBMED:11246005 EPMC:11246005 .

  3. Fatica A, Cronshaw AD, Dlakic M, Tollervey D; , Mol Cell 2002;9:341-351.: Ssf1p prevents premature processing of an early pre-60S ribosomal particle. PUBMED:11864607 EPMC:11864607 .

  4. Wehner KA, Baserga SJ; , Mol Cell 2002;9:329-339.: The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. PUBMED:11864606 EPMC:11864606.