Mus_caroliFamily: DRY_EERY Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Sfswap
Clasrp

Introduction

Pfam

This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA [1]. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains PF01805 and an Arginine- serine-rich binding region towards the C-terminus.

InterPro

This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) splice factor proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA [PUBMED:8206918]. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing.

Reference

  1. Denhez F, Lafyatis R; , J Biol Chem. 1994;269:16170-16179.: Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot. PUBMED:8206918 EPMC:8206918.