EuRBPDB

Drosophila_melanogasterFamily: Dicer_dimer Number of Genes: 2
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Dcr-2
Dcr-1

Introduction

Pfam

This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [1,2]. It is a divergent double stranded RNA-binding domain [3]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [4]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [4].

InterPro

This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [PUBMED:16424907, PUBMED:17666393]. It is a divergent double stranded RNA-binding domain [PUBMED:16954143]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [PUBMED:20106953]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [PUBMED:20106953].

Reference

  1. Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN;, EMBO J. 2006;25:522-532.: The role of PACT in the RNA silencing pathway. PUBMED:16424907 EPMC:16424907 .

  2. Ye X, Paroo Z, Liu Q;, J Biol Chem. 2007;282:28373-28378.: Functional anatomy of the Drosophila microRNA-generating enzyme. PUBMED:17666393 EPMC:17666393 .

  3. Dlakic M; , Bioinformatics. 2006;22:2711-2714.: DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold. PUBMED:16954143 EPMC:16954143 .

  4. Qin H, Chen F, Huan X, Machida S, Song J, Yuan YA;, RNA. 2010;16:474-481.: Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction. PUBMED:20106953 EPMC:20106953.