EuRBPDB

Drosophila_melanogasterFamily: Exo_endo_phos Number of Genes: 12

Ensembl ID	Symbol	Entrez ID
FBgn0004584	Rrp1	33500
FBgn0011725	twin	42880
FBgn0016762	angel	37748
FBgn0023508	Ocrl	31157
FBgn0030761	CG9784	32629
FBgn0034179	CG6805	36911
FBgn0034691	Synj	37517
FBgn0035421	CG12034	38396
FBgn0036273	INPP5E	39404
FBgn0051759	CG31759	326158
FBgn0259178	5PtaseI	326119
FBgn0261808	cu	41339

Introduction

Pfam

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g P27695 DNase I proteins EC:3.1.21.1 e.g. P24855 Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 O43426 Sphingomyelinase EC:3.1.4.12 P11889 and Nocturnin O35710.

InterPro

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PUBMED:10838565]. Proteins this domain is found in include: AP endonuclease proteins (EC), DNase I proteins (EC), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase (EC) and Sphingomyelinase (EC).

Reference

Dlakic M; , Trends Biochem Sci 2000;25:272-273.: Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. PUBMED:10838565 EPMC:10838565 .
Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; , Nature 1995;374:381-386.: Structure and function of the multifunctional DNA-repair enzyme exonuclease III. PUBMED:7885481 EPMC:7885481 .
Lahm A, Suck D; , J Mol Biol 1991;222:645-667.: DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. PUBMED:1748997 EPMC:1748997.