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This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with PF00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.
This domain is found in the C-terminal section of Fox-1 and its homologues, which regulate alternative splicing events by binding to 5'-UGCAUGU-3' elements [PUBMED:16537540, PUBMED:15824060].
Zhou HL, Baraniak AP, Lou H;, Mol Cell Biol. 2007;27:830-841.: Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing. PUBMED:17101796 EPMC:17101796.