Microtus_ochrogasterFamily: Fox-1_C Number of Genes: 3
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
Rbfox2
Rbfox3
Rbfox1

Introduction

Pfam

This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with PF00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.

InterPro

This domain is found in the C-terminal section of Fox-1 and its homologues, which regulate alternative splicing events by binding to 5'-UGCAUGU-3' elements [PUBMED:16537540, PUBMED:15824060].

Reference

  1. Zhou HL, Baraniak AP, Lou H;, Mol Cell Biol. 2007;27:830-841.: Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing. PUBMED:17101796 EPMC:17101796.