Saimiri_boliviensis_boliviensisFamily: MIF4G Number of Genes: 10
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
NCBP1
UPF2
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EIF4G1
EIF4G2
EIF4G3
CTIF
MIF4GD

Introduction

Pfam

MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA [1].

InterPro

MIF4G stands for middle domain of eukaryotic initiation factor 4G (eIF4G). eIF4G is a component of the translation initiation factor eIF4F complex and the cytoplasmic cap-binding protein complex (CBC). In the cytoplasm, cap binding complexes, distinct in their composition from nuclear cap-binding complexes, have important roles in the initiation of mRNA translation.

Reference

  1. Ponting CP; , Trends Biochem Sci 2000;25:423-426.: Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. PUBMED:10973054 EPMC:10973054.