EuRBPDB

Drosophila_melanogasterFamily: NTF2 Number of Genes: 5

Ensembl ID	Symbol	Entrez ID
FBgn0003321	sbr	43944
FBgn0015778	rin	47998
FBgn0028411	Nxt1	37769
FBgn0031145	Ntf-2	33078
FBgn0032680	Ntf-2r	35101

Introduction

Pfam

This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.

InterPro

Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity [PUBMED:9533885].

Reference

Stewart M, Kent HM, McCoy AJ; , J Mol Biol 1998;277:635-646.: Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. PUBMED:9533885 EPMC:9533885.