EuRBPDB

Mus_musculus_dba2jFamily: NTF2 Number of Genes: 10

Ensembl ID	Symbol	Entrez ID
MGP_DBA2J_G0018167	G3bp1	-
MGP_DBA2J_G0024642	Nxf1	-
MGP_DBA2J_G0026442	Nxt1	-
MGP_DBA2J_G0029555	G3bp2	-
MGP_DBA2J_G0033877	Nutf2-ps1	-
MGP_DBA2J_G0035842	Chm	-
MGP_DBA2J_G0035887	Nxf2	-
MGP_DBA2J_G0035893	Nxf7	-
MGP_DBA2J_G0035903	Nxf3	-
MGP_DBA2J_G0035959	Nxt2	-

Introduction

Pfam

This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.

InterPro

Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity [PUBMED:9533885].

Reference

Stewart M, Kent HM, McCoy AJ; , J Mol Biol 1998;277:635-646.: Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. PUBMED:9533885 EPMC:9533885.